gene 1,119 words KG: LATS2 2026-03-21
kind:genesection:genesstate:published
Contents

LATS2

🧬 Gene Info
Gene SymbolLATS2
Full NameLarge Tumor Suppressor Kinase 2
Chromosome13q12.11
Protein TypeSerine/Threonine Kinase
Primary Expressionneural progenitor cells of the ventricular and subventricular zones, where it cooperates with LATS1 to restrict progenitor proliferati
Amino Acids1088 aa
Exons9
PathwaysNF-κB
Ensembl IDENSG00000150457
GeneCardsLATS2
Human Protein AtlasLATS2
Associated DiseasesBreast Cancer
InteractionsRAB27A, MICRORNAS, YAP, APOPTOSIS, CANCER, AND
KG Connections41 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.41

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Hippo Signaling in 4R-Tauopathies
mechanism · KG edge: activates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: therapeutic_target
POLE — DNA Polymerase Epsilon
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

LATS2 activates RAB27A
LATS2 therapeutic_target DISC1
LATS2 therapeutic_target TLR2
LATS2 therapeutic_target APC
LATS2 therapeutic_target POLE
LATS2 regulates Breast Cell Fate
LATS2 interacts_with ESR1
LATS2 regulates Luminal Epithelial Cell Differentiation
LATS2 involved_in Tumor Suppression
LATS2 inhibits cancer