gene 1,058 words KG: LIF 2026-03-22
kind:genesection:genesstate:published
Contents

LIF — Leukemia Inhibitory Factor

🧬 Gene Info
Gene SymbolLIF
Full NameLeukemia Inhibitory Factor
AliasesPage for LIF Receptor Protein
Chromosome5p13.1
FunctionThe LIF gene encodes a 202-amino acid secreted glycoprotein that acts as a multifunctional cytokine:
Molecular Weight190 kDa
Amino Acids202 aa
Exons20
PathwaysMAPK, PI3K
UniProt IDP15018
NCBI Gene ID3977
Ensembl IDENSG00000128342
OMIM159446
GeneCardsLIF
Human Protein AtlasLIF
Associated Diseasesmultiple sclerosis
InteractionsEGFR, STAT3, EP300, SMAD3, BRD4, BDNF
KG Connections128 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.38

Related Analyses (4)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Hippo Signaling in 4R-Tauopathies
mechanism · KG edge: activates
Hedgehog Signaling in Neurodegeneration
mechanism · KG edge: activates
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: therapeutic_target
GEM Gene
gene · KG edge: activates
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates

Knowledge Graph (12 edges)

LIF activates EGFR
LIF protects_against neurite damage
LIF expressed_in LIFR
LIF activates STAT3
LIF activates EP300
LIF activates SMAD3
LIF activates BRD4
LIF expressed_in GFAP
LIF activates BDNF
LIF activates LIFR