gene 749 words KG: LIFR 2026-03-24
kind:genesection:genesstate:published
Contents

LIFR - Leukemia Inhibitory Factor Receptor

🧬 Gene Info
Gene SymbolLIFR
Full NameLIFR - Leukemia Inhibitory Factor Receptor
AliasesPage for LIFR
Chromosome5p13.1
Protein TypeGene
FunctionLIFR forms a signaling complex with gp130 (IL6ST)
PathwaysPI3K, MAPK, NF-κB, Wnt signaling
UniProt IDP15090
NCBI Gene ID3977
GeneCardsLIFR
Human Protein AtlasLIFR
Associated Diseasesgastric cancer, neurodegeneration, renal interstitial fibrosis
InteractionsSTAT3, LIF, EP300, SMAD3, BRD4, CANCER
KG Connections32 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (8)

SMAD3 — SMAD Family Member 3
gene · KG edge: activates
LIF — Leukemia Inhibitory Factor
gene · KG edge: activates
JAK1 — Janus Kinase 1
gene · KG edge: activates
EP300 Gene
gene · KG edge: activates
BRD4 (Bromodomain-Containing Protein 4)
gene · KG edge: activates

Knowledge Graph (12 edges)

LIFR activates JAK1
LIFR expressed_in GFAP
LIFR expressed_in LIF
LIFR activates STAT3
LIFR activates LIF
LIFR activates EP300
LIFR activates SMAD3
LIFR activates BRD4
LIFR activates Radial Glia
LIFR activates Leukemia