gene 1,772 words KG: CNTF
Contents

CNTF Gene

🧬 Gene Info
Gene SymbolCNTF
Full NameCiliary Neurotrophic Factor
Chromosome11q13.1
Protein FamilyIL-6 family of cytokines
Functionis a neuroprotective cytokine belonging to the interleukin-6 (IL-6) family of cytokines.
Primary Expressionastrocytes throughout the brain and spinal cord - Peripheral nervous system: Expressed in Schwann cells and olfactory ensh
Molecular Weight22.7 kDa
Amino Acids200 aa
PathwaysJAK-STAT signaling, MAPK Pathway, PI3K, MAPK
UniProt IDP26441
NCBI Gene ID1270
Ensembl IDENSG00000261349
OMIM118425
GeneCardsCNTF
Human Protein AtlasCNTF
Associated DiseasesALS, Alzheimer's disease, Parkinson's disease
Known Drugs/Compoundsmetformin
InteractionsAMPK, AND, BDNF, CYTOKINES, EPILEPSY, GDNF
KG Connections40 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Ocular Immune Privilege Extension
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
CYP46A1 Overexpression Gene Therapy
Score: 0.77
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38

Related Analyses (4)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Astrocytes
cell · KG edge: transports
Neurodegeneration
disease · KG edge: implicated_in
Astrocytes
entity · KG edge: transports
GDNF (Redirect)
redirect · KG edge: associated_with
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: transports

Knowledge Graph (12 edges)

BDNF associated_with CNTF
CNTF associated_with GDNF
LIF inhibits CNTF
CNTF inhibits LIF
CNTF transports Schwann Cell
CNTF transports Cntf
BDNF activates CNTF
CNTF activates GDNF
CNTF participates_in neurotrophin signaling
CNTF activates MBP

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