gene 2,995 words KG: CAV1 2026-03-27
section:geneskind:genetopic:alzheimerstopic:parkinsons
Contents

CAV1

🧬 Gene Info
Gene SymbolCAV1
AliasesCaveolin 1, Caveolin-1
Protein TypeStructural Protein
Target ClassStructural Protein
FunctionNo established drugging mechanism for structural membrane protein
Mechanism of ActionNo established drugging mechanism for structural membrane protein
DruggabilityLow (0.35)
Clinical StageApproved
Molecular Weight22 kDa
PathwaysMAPK pathway, PI3K
UniProt IDQ2TNI1
GeneCardsCAV1
Human Protein AtlasCAV1
PathwayRegulation
PI3K/AktInhibits/activates
Associated DiseasesALS, ALZHEIMER, Anxiety, Atherosclerosis
Known Drugs/CompoundsDaidzein
InteractionsTFR1, LRP1, ABCB1, HIF1A, BECN1, CLDN5
SciDEX TargetView Target Profile (1 clinical trials)
KG Connections517 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Layer V excitatory neurons show selectively enhanced vulnera
Score: 0.51

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (5)

s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.46
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.46
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.46
Blood-Brain Barrier Aging and Neurodegeneration — From Leaka
validation · proposed · Score: 0.46
Vascular Contribution to Alzheimer's Disease — Beyond Amyloi
validation · proposed · Score: 0.46

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: contributes_to
Alzheimer Indonesia
institution · KG edge: regulates
ATG13 — Autophagy Related 13
gene · KG edge: activates
ALDH2 — Aldehyde Dehydrogenase 2
gene · KG edge: associated_with
AGO2 (Argonaute-2)
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CAV1 associated_with neurodegeneration
CAV1 interacts_with TFR1
CAV1 interacts_with LRP1
CAV1 interacts_with ABCB1
CAV1 co_discussed ABCB1
CAV1 co_discussed FCGRT
CAV1 co_discussed CLDN5
CAV1 activates HIF1A
CAV1 associated_with GAIN
CAV1 associated_with CACNA1C