gene 1,541 words KG: MAG 2026-03-31
kind:genesection:genesstate:published
Contents

MAG Gene

🧬 Gene Info
Gene SymbolMAG
Full NameMyelin-Associated Glycoprotein
Chromosome19q13.12
Protein TypeType I membrane protein, Siglec family
Functionis a critical component of the myelin sheath in the central and peripheral nervous systems.
PathwaysApoptosis, Oxidative Stress
UniProt IDP20916
NCBI Gene ID4099
Ensembl IDENSG00000141670
OMIM159460
GeneCardsMAG
Human Protein AtlasMAG
Associated DiseasesALS, Alzheimer
Known Drugs/Compoundsaducanumab
InteractionsMIRO1, PLP1, MBP, GFAP, OLIG1, SIGLEC11
KG Connections98 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

PARP1 Inhibition Therapy
Score: 0.58
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.39
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Mitochondrial Transfer Pathway Enhancement
Score: 0.44

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (14)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
HK1 — Hexokinase 1
gene · KG edge: regulates
GDI2 Gene
gene · KG edge: regulates
CNTN6 — Contactin 6
gene · KG edge: upregulates

Knowledge Graph (12 edges)

MAG inhibits MIRO1
MAG regulates HK1
MAG regulates PLCB1
MAG regulates NDUFS7
MAG regulates CAPZB
MAG regulates NDUFA4
MAG inhibits PLP1
MAG inhibits MBP
MAG inhibits GFAP
MAG regulates CD81