gene 704 words KG: MOG 2026-03-15
kind:genesection:genesstate:published
Contents

MOG Gene

🧬 Gene Info
Gene SymbolMOG
Full NameMyelin Oligodendrocyte Glycoprotein
Chromosome6p22.2
FunctionMOG is a type I transmembrane glycoprotein with an immunoglobulin-like domain.
Molecular Weight28 kDa
PathwaysComplement, Oxidative Phosphorylation
NCBI Gene ID4340
Ensembl IDENSG00000137355
GeneCardsMOG
Human Protein AtlasMOG
UniProt ID P20916| OMIM ID 159445
Associated DiseasesAD, ALS, Aging, Autoimmune, MOGAD
Known Drugs/Compoundsmetformin
InteractionsC1Q, MBP, MAG, C1QA, SYN1, OLIG2
SciDEX HypothesesOligodendrocyte White Matter Vulnerability
KG Connections260 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (19)

Oligodendrocyte White Matter Vulnerability
Score: 0.40
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.42
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59

Related Analyses (9)

Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (1)

Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (12)

Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: activates
ATG5 — Autophagy Related 5
gene · KG edge: activates
AQP4 (Aquaporin-4 Gene)
gene · KG edge: activates

Knowledge Graph (12 edges)

MOG provides_data_for ds-f2c28aed24a7
MOG activates C1Q
MOG associated_with PLP1
MOG therapeutic_target CXCL10
MOG activates MBP
MOG activates MAG
MOG co_discussed LAMP1
MOG co_discussed C1QA
MOG co_discussed NLGN1
MOG co_discussed TFEB