| Gene Symbol | MDH2 |
| Chromosome | 5p15.33 |
| Protein Type | Gene |
| Function | Malate dehydrogenase 2 (MDH2) is a mitochondrial enzyme that catalyzes the reversible oxidation of malate to oxaloacetate in the TCA cycle, using NAD+ as a cofactor. |
| Primary Expression | neurons and astrocytes where it supports oxidative phosphorylation and metabolic coupling |
| Subcellular Localization | the mitochondrial matrix and plays a central role in cellular energy metabolism, participating in critical metabolic shu |
| Amino Acids | 338 aa |
| UniProt ID | P40926 |
| GeneCards | MDH2 |
| Human Protein Atlas | MDH2 |
| Associated Diseases | neurodegeneration |
| Interactions | NDUFS3, PDHB, SDHA, SUCLG1, ALDH2, ACO2 |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |