Contents

ALDH2 — Aldehyde Dehydrogenase 2

🧬 Gene Info

Gene Symbol	ALDH2
Full Name	Aldehyde Dehydrogenase 2
Aliases	ALDH-E2
Chromosome	12q24.12
Protein Type	Enzyme
Function	Mitochondrial aldehyde detoxification enzyme
Subcellular Localization	the mitochondrial matrix. Each subunit contains:
Molecular Weight	56.4 kDa
Amino Acids	517
Pathways	Ethanol metabolism, Oxidative stress response
UniProt ID	P05091
Ensembl ID	ENSG00000111275
GeneCards	ALDH2
Human Protein Atlas	ALDH2
Catalytic domain	Contains the active site with catalytic cysteine (Cys302)
Associated Diseases	Als, Atherosclerosis, Cardiovascular, Coronary Artery Disease, Infection, Inflammation
Interactions	ACACA, AND, CPT1A, FASN, FERROPTOSIS, IL1B
KG Connections	112 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Knowledge Graph

GPX4 therapeutic_target ALDH2

OTUD5 therapeutic_target ALDH2

MTOR associated_with ALDH2

IGF2R associated_with ALDH2

CAV1 associated_with ALDH2

COMT associated_with ALDH2

HSP90AA1 associated_with ALDH2

HSPA1A associated_with ALDH2

SOD2 expressed_in ALDH2