gene 532 words KG: SDHA 2026-03-13
kind:genesection:genesstate:published
Contents

SDHA Gene - Succinate Dehydrogenase Complex Subunit A

🧬 Gene Info
Gene SymbolSDHA
Full NameSuccinate Dehydrogenase Complex Subunit A
AliasesPage for SDHA Gene, Page for SDHA Protein
Chromosome5p15.33
Protein TypeEnzyme
FunctionSDHA is a catalytic subunit of succinate dehydrogenase (SDH), a heterotetrameric enzyme that functions in both the Krebs cycle (Complex II of the ETC).
Molecular Weight73 kDa
PathwaysProteasome
UniProt IDP31040
NCBI Gene ID6389
Ensembl IDENSG00000123594
GeneCardsSDHA
Human Protein AtlasSDHA
Associated DiseasesParkinson
InteractionsMFN2, BDNF, SOD2, NRF2, FNDC5, FOXO1
KG Connections170 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51

Related Analyses (7)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (11)

Packard Center for ALS Research
institution · KG edge: activates
HSPA9 Gene
gene · KG edge: activates
GLUD1 - Glutamate Dehydrogenase 1
gene · KG edge: activates
GAPDH Gene
gene · KG edge: regulates
CYCS
gene · KG edge: activates

Knowledge Graph (12 edges)

SDHA activates MFN2
SDHA activates BDNF
SDHA activates SOD2
SDHA activates NRF2
SDHA activates FNDC5
SDHA activates FOXO1
SDHA activates FIS1
SDHA activates OGG1
SDHA activates SIRT3
SDHA activates MFN1