gene

ALDH2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALDH2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections

0Hypotheses

0Analyses

50Outgoing

45Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ALDH2
Full Name	Aldehyde Dehydrogenase 2
Aliases	ALDH-E2
Chromosome	12q24.12
Protein Type	Enzyme
Function	Mitochondrial aldehyde detoxification enzyme
Subcellular Localization	the mitochondrial matrix. Each subunit contains:
Molecular Weight	56.4 kDa
Amino Acids	517
Pathways	Ethanol metabolism, Oxidative stress response
UniProt ID	P05091
Ensembl ID	ENSG00000111275
GeneCards	ALDH2
Human Protein Atlas	ALDH2
4-HNE	Substrate
Associated Diseases	Als, Atherosclerosis, Cardiovascular, Coronary Artery Disease, Infection, Inflammation
Interactions	FASN, SREBF1, MDH2, TNF, IL6, IL1B
KG Connections	112 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ALDH2 — AlphaFold P05091 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ALDH2["ALDH2"] -->|"associated"| Inflammation["Inflammation"]
    style Inflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ALDH2["ALDH2"] -->|"regulates"| mitochondrial_integrity["mitochondrial integrity"]
    style mitochondrial_integrity fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ALDH2["ALDH2"] -->|"therapeutic target"| Ischemia["Ischemia"]
    style Ischemia fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ALDH2["ALDH2"] -->|"therapeutic target"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ALDH2["ALDH2"] -->|"therapeutic target"| Tumor["Tumor"]
    style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ALDH2["ALDH2"] -->|"therapeutic target"| Parkinson["Parkinson"]
    style Parkinson fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ALDH2["ALDH2"] -->|"therapeutic target"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| ALDH2["ALDH2"]
    style FERROPTOSIS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GPX4["GPX4"] -->|"therapeutic target"| ALDH2["ALDH2"]
    style GPX4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OTUD5["OTUD5"] -->|"therapeutic target"| ALDH2["ALDH2"]
    style OTUD5 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"therapeutic target"| ALDH2["ALDH2"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    MTOR["MTOR"] -->|"associated"| ALDH2["ALDH2"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style ALDH2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (67)

Target	Relation	Type	Str
Inflammation	associated_with	disease	0.75
mitochondrial integrity	regulates	process	0.70
Ischemia	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Coronary Artery Disease	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Als	associated_with	disease	0.65
Infection	associated_with	disease	0.65
Ischemia	inhibits	disease	0.65
Als	regulates	disease	0.65
Stroke	inhibits	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
RANK	expressed_in	gene	0.60
HMGCR	therapeutic_target	gene	0.60
FASN	activates	gene	0.60
SREBF1	activates	gene	0.60
AKT	therapeutic_target	gene	0.60
APOE	associated_with	gene	0.60
MDH2	interacts_with	gene	0.60
TNF	activates	gene	0.60
MTOR	associated_with	gene	0.60
TARDBP	regulates	gene	0.60
LGALS1	regulates	gene	0.60
FASN	regulates	gene	0.60
CDK1	regulates	gene	0.60
CTSB	regulates	gene	0.60
CTSD	regulates	gene	0.60
IL6	activates	gene	0.60
PPARG	associated_with	gene	0.60
AKT	associated_with	gene	0.60
CGAS	associated_with	gene	0.60
IL1B	activates	gene	0.60
PPARA	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
Mapk	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
Mitophagy	activates	pathway	0.60
Glycolysis	activates	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60

Incoming (45)

Source	Relation	Type	Str
GPX4	therapeutic_target	gene	0.60
OTUD5	therapeutic_target	gene	0.60
MTOR	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
CAV1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
SOD2	expressed_in	gene	0.60
SIRT3	activates	gene	0.60
TNF	activates	gene	0.60
IL1B	activates	gene	0.60
PPARA	activates	gene	0.60
PI3K	therapeutic_target	gene	0.60
IL6	activates	gene	0.60
PPARG	therapeutic_target	gene	0.60
MMP12	associated_with	gene	0.60
HDAC9	associated_with	gene	0.60
FASN	activates	gene	0.60
HMGCR	therapeutic_target	gene	0.60
SREBF1	activates	gene	0.60
AKT	therapeutic_target	gene	0.60
HMGCR	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
USP14	associated_with	gene	0.60
FERROPTOSIS	activates	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
INFLAMMATION	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
ROS	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
PERICYTE	associated_with	gene	0.60
AND	activates	gene	0.60
MAPK	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
MAPK	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
STROKE	inhibits	gene	0.60
LDHA	regulates	gene	0.60
ACACA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ALDH2

Understanding Entity Pages

Wiki Pages (12)

ALDH2 — Aldehyde Dehydrogenase 2

NRF2 Oxidative Stress Pathway

ALDH1L1

HDAC9 Gene

Dopamine Neurons in Ventral Tegmental Area

ALDH1A3 Protein

mitochondrial-dysfunction-ad

ALDH2 Protein — Aldehyde Dehydrogenase 2

mdh2

ALDH1A1 Gene