gene 608 words KG: RELA 2026-03-23
kind:genesection:genesstate:published
Contents

RELA (NF-κB p65)

🧬 Gene Info
Gene SymbolNF
Full NameRELA (NF-κB p65)
AliasesNF-κB p65
Protein FamilyNF-κB transcription factors
Protein TypeTranscription Factor
FunctionRELA (p65) is a key transcription factor subunit of NF-κB.
Molecular Weight65 kDa
PathwaysNF-κB, NF-κB signaling
UniProt ID[P06579](https://www.uniprot.org/uniprot/P06579)
NCBI Gene IDSearch NCBI
GeneCardsNF
Human Protein AtlasNF
Associated DiseasesAging, Als, Cancer, Glioblastoma, Hepatitis, ISCHEMIA
Known Drugs/CompoundsRESVERATROL
InteractionsTAK1, IKBKB, IL6, LC3, AKT, AKT1
KG Connections757 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

TREM2-Dependent Microglial Senescence Transition
Score: 0.74
SASP-Mediated Complement Cascade Amplification
Score: 0.73
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.71
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.68

Related Analyses (30)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · completed
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: co_discussed
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

RELA provides_data_for ds-83b31ef18d49
RELA activates TAK1
RELA activates IKBKB
RELA activates IL6
RELA activates LC3
RELA regulates SYP
RELA regulates CHRNA7
RELA regulates SYT1
RELA regulates STAT3
RELA regulates HMOX1