gene 3,338 words KG: LRP1B 2025-03-25
kind:genesection:genesstate:published
Contents

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

🧬 Gene Info
Gene SymbolLRP1B
Full NameLow Density Lipoprotein Receptor-Related Protein 1B
AliasesPage for LRP1B Protein
Chromosome2q22.1
Protein TypeProtein
Functionis a very large LDL receptor-family transmembrane protein that functions as an endocytic and signaling regulator in epithelial and neuronal systems.
Molecular Weight500 kDa
Amino Acids595 aa
Exons92
PathwaysMAPK, PI3K, Wnt signaling
UniProt IDSearch UniProt
GeneCardsLRP1B
Human Protein AtlasLRP1B
FeatureLRP1B
Amino acids4,595
Associated DiseasesALS, Aging, Atherosclerosis, Cancer, Cardiovascular
InteractionsPAH, APOE, WNT, CANCER, APOPTOSIS, PD-1
KG Connections100 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (24)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51

Related Analyses (10)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (3)

Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40
Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauo
clinical · proposed · Score: 0.40
Tau Propagation Causality Test — Does Tau Spread Drive Neuro
clinical · proposed · Score: 0.40

See Also (15)

Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 6 hypotheses
RNA-Targeted Therapies in Neurodegeneration
mechanism · Pages share 6 hypotheses
PPAR Signaling Pathway in Neurodegeneration
mechanism · Pages share 6 hypotheses
Neurovascular Unit Dysfunction in Neurodegeneration
mechanism · Pages share 6 hypotheses
Endosomal Sorting Defects in Neurodegeneration
mechanism · Pages share 6 hypotheses

Knowledge Graph (12 edges)

LRP1B associated_with LRP4
LRP1B associated_with PAH
LRP1B associated_with LDLR
LRP1B associated_with LRP5
LRP1B associated_with LRP1
LRP1B associated_with LRP8
LRP1B associated_with LRP2
LRP1B associated_with RYR2
LRP1B associated_with EGFR
LRP1B associated_with TP53