concept

COX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

170Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	COX2
Key Genes/Proteins	NCOA4
Related Diseases	Parkinson, Neurodegeneration, Alzheimer, Cancer, Neuroinflammation
Related Pathways	Autophagy, Mtor, Ferroptosis, Oxidative Stress, Apoptosis

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    COX2["COX2"]
    COX2 -->|"activates"| Parkinson["Parkinson"]
    COX2 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    COX2 -->|"activates"| Alzheimer["Alzheimer"]
    COX2 -->|"activates"| Cancer["Cancer"]
    COX2 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    COX2 -->|"activates"| Autophagy["Autophagy"]
    COX2 -->|"activates"| Mtor["Mtor"]
    COX2 -->|"expressed in"| Ferroptosis["Ferroptosis"]
    Rotenone["Rotenone"] -->|"upregulates"| COX2
    LC3["LC3"] -->|"activates"| COX2
    NRF2["NRF2"] -->|"activates"| COX2
    FERROPTOSIS["FERROPTOSIS"] -->|"expressed in"| COX2
    FER["FER"] -->|"expressed in"| COX2
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| COX2
    NCOA4["NCOA4"] -->|"expressed in"| COX2
    ROS["ROS"] -->|"activates"| COX2

Outgoing (115)

Target	Relation	Type	Str
FERROPTOSIS	promotes	process	0.80
oxidative stress	upregulates	process	0.80
Parkinson	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Autophagy	activates	pathway	0.60
Mtor	activates	pathway	0.60
Ferroptosis	expressed_in	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Notch	activates	pathway	0.60
NCOA4	expressed_in	gene	0.60
HO-1	activates	gene	0.60
MTOR	activates	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
PARKINSON	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Neuron	activates	cell_type	0.60
Caspase	activates	protein	0.60
Α-Synuclein	activates	protein	0.60
P62	activates	gene	0.60
FER	expressed_in	gene	0.60
LC3	activates	gene	0.60
XCT	expressed_in	gene	0.60
BCL-2	activates	gene	0.60
AND	expressed_in	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
NEURON	activates	gene	0.60
NRF2	activates	gene	0.60
BAX	activates	gene	0.60
ATG5	activates	gene	0.60
GPX4	expressed_in	gene	0.60
Bcl-2	activates	protein	0.60
S100A9	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
ATP	inhibits	gene	0.60
OSMR	activates	gene	0.60
LCN2	activates	gene	0.60
DRP1	activates	gene	0.60
CASP4	activates	gene	0.60
SOCS3	activates	gene	0.60
Mitochondrial Function	activates	pathway	0.60
Rb	activates	protein	0.60
Actin	activates	protein	0.60
Nfkb	activates	protein	0.60
Ras	activates	protein	0.60
MICROGLIA	inhibits	gene	0.60

Incoming (55)

Source	Relation	Type	Str
Rotenone	upregulates	compound	0.90
LC3	activates	gene	0.60
NRF2	activates	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
FER	expressed_in	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NCOA4	expressed_in	gene	0.60
ROS	activates	gene	0.60
ATG5	activates	gene	0.60
NEURON	activates	gene	0.60
XCT	expressed_in	gene	0.60
BCL-2	activates	gene	0.60
BAX	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
HO-1	activates	gene	0.60
AND	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
P62	activates	gene	0.60
PARKINSON	activates	gene	0.60
GPX4	expressed_in	gene	0.60
MTOR	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
PRESENILIN-1	regulates	gene	0.60
PRESENILIN	regulates	gene	0.60
NOTCH1	activates	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
CANCER	activates	gene	0.60
PSEN1	activates	gene	0.60
MTDNA	activates	gene	0.60
S100A8	activates	gene	0.60
HMGB1	inhibits	gene	0.60
NCOR1	inhibits	gene	0.60
ASC	inhibits	gene	0.60
CCL2	expressed_in	gene	0.60
CCL5	expressed_in	gene	0.60
AIFM1	activates	gene	0.60
ATP5A1	activates	gene	0.60
CALCOCO2	activates	gene	0.60
CAT	inhibits	gene	0.60
ATP	activates	gene	0.60
CD8	activates	gene	0.60
ATF6	activates	gene	0.60
CHOP	activates	gene	0.60
BAX	associated_with	gene	0.48
CASP3	associated_with	gene	0.48
LC3	associated_with	protein	0.48
MTOR	associated_with	gene	0.48

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

COX2

Understanding Entity Pages

Wiki Pages (20)

omega-3-fatty-acids-neurodegeneration

Curcumin for Neurodegeneration

COX20 Gene - Cytochrome c Oxidase Assembly Factor

TFAM Gene

surf1

COX14 — Cytochrome C Oxidase Assembly Factor 14

SCO1 — Cytochrome c Oxidase Assembly Factor SCO1

COA6 Gene - Cytochrome c Oxidase Assembly Factor 6

COA8 Gene - Cytochrome c Oxidase Assembly Factor 8

PET117 — Cytochrome C Oxidase Assembly Factor

COX8A Gene

EARS2 — Mitochondrial Glutamyl-tRNA Synthetase

COX4I1

SCO2 — Cytochrome c Oxidase Assembly Factor SCO2

Mitochondrial Complex IV (Cytochrome c Oxidase)

CEBPE Gene

IL1A — Interleukin 1 Alpha

COX7A2 Gene