gene 1,544 words KG: NFATC2
Contents

NFATc2 — Nuclear Factor of Activated T Cells 2

🧬 Gene Info
Gene SymbolNFATc2 / NFATC2
AliasesNFAT1, NF-AT2, NFATc2
Chromosome20q13.12
Protein TypeTranscription Factor
Functionis a member of the NFAT (Nuclear Factor of Activated T cells) transcription factor family involved in calcium-dependent gene regulation.
Subcellular Localizationand protein interactions
Amino Acids925 aa
Pathwayscascade: [@crabtree2001]
UniProt IDQ13469
NCBI Gene ID4778
ProteinNuclear factor of activated T-cells, cytoplasmic 2
GeneFunction
BDNFNeurotrophin
COX-2Inflammatory enzyme
iNOSNitric oxide synthase
Associated Diseasesneurodegeneration
InteractionsCTSB, MICROGLIA, PI3K, TPX2, LC3, AURKA
KG Connections33 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Blood Biomarker vs Tau PET for Treatment Monitoring
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40
Levodopa-Induced Dyskinesias Mechanism — Experiment Design
validation · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (11)

Interferon Signaling in Neurodegeneration
mechanism · KG edge: regulates
Angiogenesis Pathway
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
MAP1LC3A Gene
gene · KG edge: activates
CTSB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

NFATC2 activates CTSB
NFATC2 activates Cancer
NFATC2 activates Als
NFATC2 activates Autophagy
NFATC2 activates Angiogenesis
NFATC2 regulates NEUROINFLAMMATION
NFATC2 regulates AND
NFATC2 regulates GENES
NFATC2 activates MICROGLIA
NFATC2 regulates IFN