gene 1,255 words KG: OGDH 2026-03-28
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

OGDH — Oxoglutarate Dehydrogenase

🧬 Gene Info
Gene SymbolOGDH
Full NameOxoglutarate Dehydrogenase
Chromosome7p13
Protein Family2-oxoacid dehydrogenase family
Protein TypeEnzyme
Functionis a critical metabolic enzyme whose activity is significantly reduced in aging brain and in neurodegenerative diseases including Alzheimer's disease (AD) and Parkinson's disease (PD).
Gene TypeProtein-coding
PathwaysLipid Metabolism
UniProt IDQ02218
NCBI Gene ID4967
Ensembl IDENSG00000105953
OMIM203740
GeneCardsOGDH
Human Protein AtlasOGDH
Encoded ProteinOGDH (α-KGDH E1)
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsPINK1, PTEN, SOD1, MTORC1, MITOCHONDRIAL DYSFUNCTION, DNA
KG Connections42 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

APOE-Dependent Autophagy Restoration
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (2)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

LRRK2 G2019S Transgenic Mouse Model
model · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: therapeutic_target
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: therapeutic_target
PARKIN Gene
gene · KG edge: associated_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates

Knowledge Graph (12 edges)

OGDH associated_with PINK1
OGDH associated_with UBIQUITIN
OGDH associated_with SOD1
OGDH associated_with GBA
OGDH associated_with PARKIN
OGDH associated_with LRRK2
OGDH activates PINK1
OGDH activates PTEN
OGDH activates SOD1
OGDH therapeutic_target Als