gene 690 words KG: CREB1 2026-03-24
kind:genesection:genesstate:published
Contents

CREB1 Gene

🧬 Gene Info
Gene SymbolCREB1
Full NamecAMP Response Element Binding Protein 1
Chromosome2q33.3
Protein TypeTranscription Factor
FunctionCREB1 is a transcription factor that regulates gene expression in response to cAMP and calcium signaling.
Primary Expressionbrain, with high levels in hippocampus, cortex, and striatum
Molecular Weight37 kDa
PathwaysApoptosis, CREB signaling, MAPK signaling, Mapk, Oxidative Phosphorylation
UniProt IDP16220
NCBI Gene ID1385
Ensembl IDENSG00000108748
OMIM123810
GeneCardsCREB1
Human Protein AtlasCREB1
Associated DiseasesBreast Cancer, Cancer, neurodegeneration
InteractionsPPARGC1A, BCL2, NDUFA1, SLC2A1, BDNF, synaptic plasticity genes
KG Connections241 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
Digital Twin-Guided Metabolic Reprogramming
Score: 0.76
HDAC3-Selective Inhibition for Clock Reset
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65

Related Analyses (14)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

See Also (15)

OSK Reprogramming and Yamanaka Factors in Neurodegenera
mechanism · Pages share 6 hypotheses
Packard Center for ALS Research
institution · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: co_discussed
CANX — Calnexin
gene · KG edge: expressed_in
CALB2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CREB1 provides_data_for ds-83b31ef18d49
CREB1 activates PPARGC1A
CREB1 co_discussed LAMP1
CREB1 co_discussed TFEB
CREB1 interacts_with BCL2
CREB1 activates NDUFA1
CREB1 activates SLC2A1
CREB1 co_discussed HMGCR
CREB1 co_discussed mitochondrial biogenesis genes
CREB1 co_discussed Disease-causing mutations with integrated reporters

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