gene 2,320 words KG: PNKP 2026-03-26
kind:genesection:genestopic:parkinsonstopic:dna-repairtopic:ataxia
Contents

PNKP - Polynucleotide Kinase 3'-Phosphatase

🧬 Gene Info
Gene SymbolPNKP
Full NamePNKP - Polynucleotide Kinase 3'-Phosphatase
AliasesPage for PNKP Protein
Chromosome19q13.33
Protein TypeGene
Functionis a critical DNA repair enzyme that plays an essential role in maintaining genomic integrity in post-mitotic neurons.
Molecular Weight47 kDa
Amino Acids515 aa
Exons19
UniProt IDQ96T60
NCBI Gene ID11277
Ensembl IDENSG00000136717
GeneCardsPNKP
Human Protein AtlasPNKP
Associated DiseasesParkinson's disease
InteractionsFEN1, XPF, XRCC1, XPG, TDP1, SETX
KG Connections44 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

PARP1 Inhibition Therapy
Score: 0.58
R-Loop Resolution Enhancement Therapy
Score: 0.43
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (7)

Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
SETX Gene
gene · KG edge: activates
FEN1 — Flap Endonuclease 1
gene · KG edge: activates

Knowledge Graph (12 edges)

PNKP provides_data_for ds-83b31ef18d49
PNKP activates FEN1
PNKP activates XPF
PNKP activates XRCC1
PNKP activates XPG
PNKP activates TDP1
PNKP activates SETX
PNKP encodes XPG
PNKP encodes FEN1
PNKP activates Rb