gene 626 words KG: TDP1 2026-03-22
kind:genesection:genesstate:published
Contents

TDP1 Gene

🧬 Gene Info
Gene SymbolTDP1
Full NameTyrosyl-DNA Phosphodiesterase 1
Chromosome14q32.12
FunctionThe TDP1 gene encodes Tyrosyl-DNA Phosphodiesterase 1, involved in DNA repair and genomic stability
UniProt IDQ9NZJ8
NCBI Gene ID70099
Ensembl IDENSG00000124564
OMIM605197
GeneCardsTDP1
Human Protein AtlasTDP1
Associated Diseasesneurodegeneration
InteractionsPNKP, FEN1, XPF, XRCC1, SETX, HIF1A
KG Connections43 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
R-Loop Resolution Enhancement Therapy
Score: 0.43

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40

See Also (13)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: therapeutic_target
erk-mapk-signaling-neurodegeneration
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
SETX Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TDP1 activates PNKP
TDP1 inhibits FEN1
TDP1 inhibits XPF
TDP1 activates XRCC1
TDP1 activates SETX
TDP1 therapeutic_target MAPK1
TDP1 therapeutic_target CTSD
TDP1 interacts_with HIF1A
TDP1 inhibits XPG
TDP1 inhibits Rb