| Gene Symbol | XRCC1 |
| Protein Type | Scaffold Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | all tissues:
- High expression in brain (neurons, glia)
- Moderate expression in other proliferating cells
- Induced by oxidative stress
- Cell type-s |
| Molecular Weight | 69 kDa |
| Amino Acids | 633 aa |
| Pathways | epigenetic regulation, neurotrophin signaling |
| GeneCards | XRCC1 |
| Human Protein Atlas | XRCC1 |
| DNA glycosylases | Damage recognition |
| APE1 | AP site cleavage |
| Pol β | DNA synthesis |
| LIG3 | DNA ligation |
| PARP1 | SSB detection |
| Approach | Status |
| Associated Diseases | Cancer, Fibrosis |
| Interactions | SETX, FEN1, PNKP, TDP1, XPF, XPG |
| KG Connections | 58 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |