| Gene Symbol | ERCC4 (formerly XPF) |
| Aliases | ERCC4 (XPF) |
| Chromosome | 16p13.12 |
| Function | The complex recognizes and cleaves DNA at the 5' side of various DNA lesions, including |
| Primary Expression | all human tissues with particularly high levels in:
- Testis: Highest expression (germ cell DNA repair)
- Skin: High basal expression (UV expo |
| Molecular Weight | ~104 kDa |
| Amino Acids | 966 aa |
| UniProt ID | Q92841 |
| NCBI Gene ID | 2072 |
| OMIM | 278760 |
| Protein Length | 966 amino acids |
| ERCC1 | Heterodimer formation, substrate recognition |
| XPA | Damage verification, complex recruitment |
| XPC | Global genome NER damage recognition |
| TFIIH | Transcription-repair coupling |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | XRCC1, PNKP, XPG, TDP1, FEN1, SETX |
| KG Connections | 42 knowledge graph edges |
| Databases | GeneCardsHPASTRING |