gene 1,741 words KG: PRKAB1 2026-03-25
kind:genesection:genesstate:published
Contents

PRKAB1 — Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1

🧬 Gene Info
Gene SymbolPRKAB1
Full NameProtein Kinase AMP-Activated Non-Catalytic Subunit Beta 1
AliasesAMPK beta-1 subunit
Chromosome12q24.31
Functionis a central cellular energy sensor that plays a critical role in regulating energy homeostasis across all eukaryotic cells.
Subcellular LocalizationPRKAB1 (beta-1) is the predominant isoform in most tissues
Molecular Weight~30 kDa
Amino Acids270 aa
PathwaysAMPK, AMPK signaling
UniProt IDQ9Y478
NCBI Gene ID5564
Ensembl IDENSG00000111725
OMIM602636
GeneCardsPRKAB1
Human Protein AtlasPRKAB1
Associated Diseasesneurodegeneration
InteractionsAMPK, AND, Ras
KG Connections33 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
APOE-Dependent Autophagy Restoration
Score: 0.61
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (13)

NME1 - NME Nucleoside Diphosphate Kinase 1
gene · KG edge: therapeutic_target
EPAS1 Gene
gene · KG edge: therapeutic_target
CTSD — Cathepsin D
gene · KG edge: therapeutic_target
CNR1 Gene
gene · KG edge: therapeutic_target
CHRNA2 — Cholinergic Receptor Nicotinic Alpha 2
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

PRKAB1 therapeutic_target CACNA1E
PRKAB1 therapeutic_target CNR1
PRKAB1 therapeutic_target EPAS1
PRKAB1 therapeutic_target CTSD
PRKAB1 therapeutic_target CEBPA
PRKAB1 therapeutic_target CACNA2D3
PRKAB1 inhibits aerobic glycolysis
PRKAB1 inhibits Obesity
PRKAB1 inhibits Diabetes
PRKAB1 inhibits AMPK