gene 1,410 words KG: EPAS1 2026-03-28
kind:genesection:genesstate:published
Contents

EPAS1 Gene

🧬 Gene Info
Gene SymbolEPAS1
Full NameEndothelial PAS Domain Protein 1
AliasesHIF-2α
Chromosome2p21
Protein TypeTranscription Factor
Functionis a transcription factor that serves as the master regulator of cellular responses to hypoxia.
Amino Acids870 aa
Exons16
PathwaysApoptosis, MAPK signaling, Reactive Oxygen Species, apoptosis, apoptosis pathway
UniProt IDQ9Y5Q3
NCBI Gene ID2034
Ensembl IDENSG00000177640
OMIM603349
GeneCardsEPAS1
Human Protein AtlasEPAS1
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
InteractionsMIRO1, CTSD, RB1, EIF2AK3, PRKN, BCL2L11
KG Connections495 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: associated_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with
ATM Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

EPAS1 activates ERN1
EPAS1 activates FAM134B
EPAS1 activates FIP200
EPAS1 activates FMR1
EPAS1 activates FUNDC1
EPAS1 activates G3BP1
EPAS1 activates GBA
EPAS1 activates HIF1A
EPAS1 activates JNK
EPAS1 activates LC3