gene 1,370 words KG: PSMB8
Contents

PSMB8

🧬 Gene Info
Gene SymbolPSMB8
Full NameProteasome Subunit Beta 8
Functionis a member of the proteasome family and encodes the β5i subunit, which is primarily expressed in immune cells and becomes the catalytically active component of the immunoproteasome.
Primary Expressionimmune cells and becomes the catalytically active component of the immunoproteasome
Molecular Weight30.3 kDa
Amino Acids276 aa
PathwaysNf-Κb
Ensembl IDENSG00000240065
GeneCardsPSMB8
Human Protein AtlasPSMB8
Associated DiseasesInflammation, Multiple Sclerosis, Neurodegeneration
InteractionsALPHA-SYNUCLEIN, ASTROCYTE, ASTROCYTES, AUTOPHAGY, COMPLEMENT, NEURODEGENERATION
KG Connections61 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

Purinergic Signaling Polarization Control
Score: 0.71
Extracellular Matrix Stiffness Modulation
Score: 0.69

Related Analyses (2)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40

See Also (12)

Astrocytes
cell · KG edge: activates
Parkinson Basal Ganglia Circuit
circuit · KG edge: activates
NeuRon Therapeutics
company · KG edge: activates
Neurodegeneration
disease · KG edge: activates
Astrocytes
entity · KG edge: activates

Knowledge Graph (12 edges)

SAMHD1 associated_with PSMB8
TREX1 associated_with PSMB8
IKBKG regulates PSMB8
TLR2 activates PSMB8
PSMB8 causes Rb
PSMB8 associated_with SAMHD1
PSMB8 associated_with TREX1
PSMB8 regulates Als
PSMB8 regulates Ms
PSMB8 regulates Nf-Κb

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