gene 614 words KG: RAB8A 2026-03-21
kind:genesection:genesstate:published
Contents

RAB8A — RAB8A, Member RAS Oncogene Family

🧬 Gene Info
Gene SymbolRAB8A
Full NameRAB8A, Member RAS Oncogene Family
AliasesRas-Related Protein
Chromosome19p13.2
FunctionRAB8A encodes a member of the Rab GTPase family, which are key regulators of intracellular vesicle trafficking
Molecular Weight24 kDa
PathwaysCholesterol
UniProt IDP61006
NCBI Gene ID51528
Ensembl IDENSG00000135569
OMIM608030
GeneCardsRAB8A
Human Protein AtlasRAB8A
StrategyDrug/Approach
ModulatorCID-1067700 (Rab inhibitor)
Associated Diseasesneurodegeneration
InteractionsNPC1, SMCR8, C9ORF72, SNAP23, STX4, ALS
KG Connections60 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Lysosomal Enzyme Trafficking Correction
Score: 0.49
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.41

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

See Also (15)

IGF2R Protein
protein · KG edge: therapeutic_target
LRRK2 G2019S Transgenic Mouse Model
model · KG edge: phosphorylates
Packard Center for ALS Research
institution · KG edge: inhibits
Dementia Australia
institution · KG edge: inhibits
RAB7A — RAB7A, Member RAS Oncogene Family
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

RAB8A inhibits NPC1
RAB8A therapeutic_target CANX
RAB8A therapeutic_target HSPA5
RAB8A regulates RAB11A
RAB8A regulates DNAJC5
RAB8A regulates ATG7
RAB8A regulates VAMP7
RAB8A regulates UBIQUITIN
RAB8A regulates RAB27A
RAB8A inhibits SMCR8