gene 819 words KG: ATG7 2026-03-24
kind:genesection:genesstate:published
Contents

ATG7 Gene

🧬 Gene Info
Gene SymbolATG7
Full NameAutophagy Related 7
Chromosome3p22.1
Protein TypeProtein
Functionis an essential E1-like activating enzyme that plays a central role in the execution of macroautophagy.
Molecular Weight78 kDa
Gene TypeProtein-coding
PathwaysAngiogenesis, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
UniProt IDO95352
NCBI Gene ID9459
Ensembl IDENSG00000198271
OMIM607760
GeneCardsATG7
Human Protein AtlasATG7
DiseaseInheritance
Associated DiseasesALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/CompoundsRAPAMYCIN, CURCUMIN, curcumin, nicotinamide, rapamycin
InteractionsJUN, SQSTM1, MAP2, SYN1, MAP1LC3B, SNAP25
KG Connections1342 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58

Related Analyses (20)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: degrades
Gene Page: ALS4 (SENATAXIN)
gene · KG edge: associated_with
AKT1 Gene
gene · KG edge: activates
AIF1 Gene
gene · KG edge: associated_with
ACTB Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ATG7 co_discussed LC3
ATG7 expressed_in CTSB
ATG7 expressed_in CTSD
ATG7 activates DNMT1
ATG7 activates GABARAP
ATG7 activates HTT
ATG7 activates HUNTINGTIN
ATG7 activates SETX
ATG7 activates SMN1
ATG7 activates WIPI2