gene 819 words KG: ent-gene-1aae10b5
Contents

ATG7 Gene

🧬 Gene Info
Gene SymbolATG7
Full NameAutophagy Related 7
Chromosome3p22.1
Protein TypeProtein
Functionis an essential E1-like activating enzyme that plays a central role in the execution of macroautophagy.
Molecular Weight78 kDa
PathwaysAngiogenesis, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
UniProt IDO95352
NCBI Gene ID9459
Ensembl IDENSG00000198271
OMIM607760
GeneCardsATG7
Human Protein AtlasATG7
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compoundscurcumin, CURCUMIN, nicotinamide, rapamycin, RAPAMYCIN
InteractionsACETYL-COA, ACHE, ACSL4, ACTB, Actin, AD
SciDEX HypothesesAstrocyte-specific autophagy deficiency induces NA
Autophagy Enhancement for Tau Clearance
Oligodendroglial Autophagy Enhancement
KG Connections1420 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (50)

APOE-Dependent Autophagy Restoration
Score: 0.89
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.89
Transcriptional Autophagy-Lysosome Coupling
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Circadian Clock-Autophagy Synchronization
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
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Related Analyses (22)

Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completed
Does TRPML1 enhancement cause therapeutic benefit or paradox
neurodegeneration · completed
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (6)

ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: biomarker_for
ACTB Gene
gene · KG edge: associated_with
AIF1 Gene
gene · KG edge: associated_with
AKT1 Gene
gene · KG edge: activates
Gene Page: ALS4 (SENATAXIN)
gene · KG edge: associated_with

Knowledge Graph (2 edges)

SDA-2026-04-16-hyp-4a6e22aa targets ent-gene-1aae10b5
ent-gene-1aae10b5 targeted_by SDA-2026-04-16-hyp-4a6e22aa

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