gene 547 words KG: RAPTOR
Contents

RAPTOR Gene

🧬 Gene Info
Gene SymbolRAPTOR
Full NameRegulatory Associated Protein of mTORC1
AliasesRaptor protein
Chromosome17q1.32
FunctionRAPTOR (Regulatory-Associated Protein of mTOR) is an essential component of mTOR Complex 1 (mTORC1), serving as a scaffolding protein that recruits substrates to the mTOR kinase.
Primary Expressionthe nervous system: - High expression: Cerebral cortex, hippocampus, basal forebrain - Mo
Molecular Weight149 kDa
Pathwaysmtor, mTOR, PI3K, AMPK
UniProt IDQ8N122
Ensembl IDENSG00000141551
GeneCardsRAPTOR
Human Protein AtlasRAPTOR
Associated Diseasesneurodegeneration
InteractionsACETYL-COA, ACLY, ALPHA-SYNUCLEIN, AMPK, AND, ATG5
KG Connections109 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

APOE-Dependent Autophagy Restoration
Score: 0.89
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

ATP P2X3 Receptor Neurons
cell · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ATG5 — Autophagy Related 5
gene · KG edge: inhibits

Knowledge Graph (12 edges)

P300 regulates RAPTOR
RAPTOR activates SNCA
SNCA activates RAPTOR
RAPTOR regulates axonal regeneration
RAPTOR interacts_with mTORC1
MTOR regulates RAPTOR
P62 regulates RAPTOR
ULK1 regulates RAPTOR
RAPTOR regulates LC3
MTOR inhibits RAPTOR

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