concept

P300

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P300: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

1Hypotheses

1Analyses

26Outgoing

31Incoming

0Experiments

1Debates

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💡 Concept Info

Name	P300
Key Genes/Proteins	ACETYL_COA, AEP, AMPK, APP, ASC1, BDNF
Related Diseases	ALS, CHROMATIN REMODELING
Related Pathways	autophagy pathway

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    P300[P300]
    P300 -->|phosphorylates| NCL[NCL]
    P300 -->|regulates| H3K9la[H3K9la]
    P300 -->|modifies| raptor[raptor]
    P300 -->|phosphorylates| RPTOR[RPTOR]
    P300 -->|regulates| AUTOPHAGY[AUTOPHAGY]
    P300 -->|regulates| FOXO3[FOXO3]
    P300 -->|inhibits| APP[APP]
    P300 -->|activates| BRD4[BRD4]
    P300 -->|inhibits| METASTASIS[METASTASIS]
    P300 -->|regulates| TFEB[TFEB]
    ACLY[ACLY] -->|activates| P300
    Acetyl_CoA[Acetyl-CoA] -->|activates| P300
    ASC1[ASC1] -->|interacts| P300
    andrographolide[andrographolide] -->|binds_to| P300
    AMPK[AMPK] -->|inhibits| P300
    TAU[TAU] -->|activates| P300
    BDNF[BDNF] -->|activates| P300
    ALS[ALS] -->|treats| P300
    LACTATE[LACTATE] -->|activates| P300

Outgoing (26)

Target	Relation	Type	Str
NCL	phosphorylates	protein	0.90
H3K9la	regulates	phenotype	0.85
raptor	modifies	protein	0.80
RPTOR	phosphorylates	protein	0.80
AUTOPHAGY	regulates	process	0.80
NFE2L2	regulates	protein	0.70
BACE1 transcription	regulates	process	0.70
FOXO3	regulates	gene	0.70
APP	inhibits	gene	0.70
BRD4	activates	gene	0.65
METASTASIS	inhibits	phenotype	0.65
CHROMATIN REMODELING	causes	phenotype	0.60
oxidative stress response	participates_in	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
LONG-TERM POTENTIATION	inhibits	phenotype	0.60
TFEB	regulates	gene	0.60
DNA METHYLATION	activates	phenotype	0.60
SIRT1	interacts_with	gene	0.60
AUTOPHAGY	destabilizes	phenotype	0.60
epigenetic regulation	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
RAPTOR	regulates	protein	0.56
LONG-TERM POTENTIATION	implicated_in	phenotype	0.55
cholinergic neurons	expressed_in	cell_type	0.55
ALS	associated_with	disease	0.50

Incoming (31)

Source	Relation	Type	Str
ACLY	activates	protein	0.90
Acetyl-CoA	activates	compound	0.85
AMPK	inhibits	protein	0.80
ASC1	interacts_with	protein	0.80
andrographolide	binds_to	drug	0.80
ALS	treats	disease	0.70
salicylates	inhibits	drug	0.70
BDNF	activates	gene	0.70
BDNF	regulates	gene	0.70
TAU	activates	protein	0.70
AMPK	causes	gene	0.65
LACTATE	activates	phenotype	0.65
ACETYL_COA	activates	protein	0.64
CREB	regulates	gene	0.60
LDL	regulates	gene	0.60
AEP	regulates	gene	0.60
CBP	interacts_with	gene	0.60
DNA METHYLATION	regulates	phenotype	0.60
EP300	interacts_with	gene	0.60
BRD4	regulates	gene	0.60
CBP	regulates	gene	0.60
FH	associated_with	gene	0.60
BRD4	activates	gene	0.60
HDAC1	regulates	gene	0.60
HDAC2	regulates	gene	0.60
HDAC3	regulates	gene	0.60
CREB	interacts_with	gene	0.60
RAPAMYCIN	associated_with	drug	0.45
PARKINSON	associated_with	disease	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
STROKE	associated_with	disease	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
p300/CBP-dependent K280 acetylation nucleates pathogenic tau	0.455	neurodegeneration	Which specific post-translational modifi

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.604

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The observation that salsalate and diflunisal decrease both AD and TBI incidence

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning P300 in their description or question text

No additional research found