mechanism 2,109 words KG: ACLY 2026-03-24
kind:mechanismsection:mechanismsstate:publishedtopic:parkinsons
Contents

ACLY Inhibition Rescues Alpha-Synuclein Autophagy

Mechanism Info
NameACLY
SummaryMechanism by which ACLY inhibition restores autophagy impaired by alpha-synuclein mutations via p300 mislocalization
Key Genes/Proteinsp300, SREBP1, alpha-synuclein, LKB1, AMPK, ACETYL_COA
Related DiseasesParkinson, Cancer, Tumor, Carcinoma

Knowledge Graph

Related Hypotheses (28)

Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Smartphone-Detected Motor Variability Correction
Score: 0.56
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Autophagosome Maturation Checkpoint Control
Score: 0.49

Related Analyses (30)

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Related Experiments (8)

Multi-omics analysis of myricanol effects on gene expression
exploratory · proposed · Score: 0.88
Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
AMPK knockdown validation experiment
exploratory · proposed · Score: 0.88
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85

See Also (6)

A53T Alpha-Synuclein Transgenic Mouse Model of Parkinso
model · KG edge: activates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates

Knowledge Graph (12 edges)

ACLY involved_in De Novo Fatty Acid Synthesis
ACLY activates ACETYL-COA
ACLY activates MTORC1
ACLY activates PARKINSON'S DISEASE
ACLY inhibits ALPHA-SYNUCLEIN
ACLY activates Parkinson
ACLY inhibits Autophagy
ACLY inhibits Alpha-Synuclein
ACLY activates Mtor
ACLY expressed_in Neuron