gene 2,944 words KG: ROCK2 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:alstopic:cytoskeletontopic:signal-transductionevidence:strong
Contents

ROCK2 Gene

🧬 Gene Info
Gene SymbolROCK2
Full NameRho-associated Protein Kinase 2
Chromosome2p24.1
Protein TypeSerine/Threonine Kinase
Functionencodes a serine/threonine kinase that functions as a major effector of the small GTPase RhoA.
Primary ExpressionUbiquitous, highest in testis
Subcellular LocalizationCytoplasmic, membrane
Molecular Weight160 kDa
Amino Acids388 aa
Exons33
PathwaysGlycolysis
GeneCardsROCK2
Human Protein AtlasROCK2
FeatureROCK1
Tissue expressionUbiquitous, highest in testis
Associated DiseasesHuntington, neurodegeneration
InteractionsPTEN, MTOR, AKT, GJA1, GNA13, CALB2
KG Connections88 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (14)

huntington-disease-treatment
therapeutic · KG edge: regulates
MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: biomarker_for
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: biomarker_for
Packard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (12 edges)

ROCK2 regulates HK2
ROCK2 activates PTEN
ROCK2 activates MTOR
ROCK2 activates AKT
ROCK2 activates GJA1
ROCK2 biomarker_for AKT
ROCK2 activates GNA13
ROCK2 biomarker_for PI3K
ROCK2 biomarker_for TAU
ROCK2 activates CALB2