gene

CALB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections
0Hypotheses
0Analyses
47Outgoing
25Incoming

Summary

CALB2 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, contributes to, implicated in. Associated with Autoimmune, Cancer, Depression. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCALB2
Chromosome16q22.2 [@wong2025]
Protein TypeGene
FunctionCALB2 encodes calretinin, a calcium-binding protein of the EF-hand family.
Primary Expressionspecific neuronal populations and is considered a neuroprotective molecule due to its calcium-buffering capacity
PathwaysMapk
UniProt IDP22676
NCBI Gene ID794
Ensembl IDENSG00000171331
GeneCardsCALB2
Human Protein AtlasCALB2
GeneExpression Level
CALB2High
SLC17A6 (VGLUT2)High
GABRA6Medium
Associated DiseasesHuntington, neurodegeneration
InteractionsRAB3B, CALB1, PVALB, S100B, GFAP, ROCK2
KG Connections72 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CALB2 — AlphaFold P22676 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Principal Olive Neurons

cell · 882 words

locus-coeruleus

brain_region · 3396 words

Cortical Ivy Cells

cell · 2948 words

Olfactory Bulb Granule Cells

cell · 2408 words

Synaptic Dysfunction in Corticobasal Syndrome

mechanism · 2341 words

Striatal Interneurons in Huntington's Disease

cell · 2034 words

Pathway Diagram

graph TD
    CALB2["<b>CALB2</b>"]
    Schizophrenia{"Schizophrenia"}
    CALB2 -->|"inhibits"| Schizophrenia
    Cancer{"Cancer"}
    CALB2 -->|"contributes to"| Cancer
    Depression{"Depression"}
    CALB2 -->|"inhibits"| Depression
    Ms{"Ms"}
    CALB2 -->|"inhibits"| Ms
    Autoimmune{"Autoimmune"}
    CALB2 -->|"contributes to"| Autoimmune
    RAB3B["RAB3B"]
    CALB2 -->|"inhibits"| RAB3B
    Epigenetic(["Epigenetic"])
    CALB2 -->|"inhibits"| Epigenetic
    Notch(["Notch"])
    CALB2 -->|"contributes to"| Notch
    neurodegeneration["neurodegeneration"]
    CALB2 -->|"implicated in"| neurodegeneration
    GFAP["GFAP"]
    GFAP -->|"inhibits"| CALB2
    CHRNA6["CHRNA6"]
    CHRNA6 -->|"inhibits"| CALB2
    CANCER["CANCER"]
    CANCER -->|"contributes to"| CALB2
    style CALB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (47)

TargetRelationTypeStr
Schizophreniainhibitsdisease0.65
Cancercontributes_todisease0.65
Depressioninhibitsdisease0.65
Msinhibitsdisease0.65
Autoimmunecontributes_todisease0.65

Incoming (25)

SourceRelationTypeStr
GFAPinhibitsgene0.60
CHRNA6inhibitsgene0.60
MAPK1activatesgene0.60
CREB1activatesgene0.60
NTRK3activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found