gene 1,098 words KG: SCNN1A 2026-03-25
kind:genesection:genestopic:alzheimerstopic:parkinsons
Contents

SCNN1A Gene

🧬 Gene Info
Gene SymbolSCNN1A
Full NameSodium Channel Epithelial Subunit Alpha
Chromosome12p13.31
Protein TypeChannel
Functionencodes the α-subunit of the epithelial sodium channel (ENaC), also known as the amiloride-sensitive sodium channel
Primary Expressionsubstantia nigra neurons
UniProt IDP37088
NCBI Gene ID6337
Ensembl IDENSG00000111319
OMIM600228
GeneCardsSCNN1A
Human Protein AtlasSCNN1A
Protein NameENaC α subunit (Alpha-ENaC)
SubunitGene
α (alpha)SCNN1A
Associated DiseasesCancer
KG Connections100 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
Extracellular Matrix Stiffness Modulation
Score: 0.43

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Hippo Signaling in 4R-Tauopathies
mechanism · KG edge: associated_with
KCNN4 — Potassium Calcium-Activated Channel Subfamily N
gene · KG edge: associated_with
KCNMA1 Gene
gene · KG edge: associated_with
KCNK2 Gene
gene · KG edge: associated_with
CFTR Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SCNN1A associated_with TRPM7
SCNN1A associated_with TRPV4
SCNN1A associated_with CFTR
SCNN1A associated_with PIEZO2
SCNN1A associated_with TRPA1
SCNN1A associated_with KCNMA1
SCNN1A associated_with TRPV1
SCNN1A associated_with KCNN4
SCNN1A associated_with KCNQ1
SCNN1A associated_with CACNA1C