gene 1,374 words KG: KCNN4 2026-03-27
kind:genesection:genesstate:publishedtopic:ion-channelstopic:neuroinflammationtopic:immune-system
Contents

KCNN4 — Potassium Calcium-Activated Channel Subfamily N Member 4

🧬 Gene Info
Gene SymbolKCNN4
Full NamePotassium Calcium-Activated Channel Subfamily N Member 4
AliasesSK4, IK1, KCa3.1
Chromosome19q13.2
Protein TypeIon channel (intermediate-conductance Ca²⁺-activated K⁺)
Functionis an intermediate-conductance calcium-activated potassium channel that plays critical roles in immune cell activation, erythrocyte volume regulation, epithelial secretion, and neuroinflammation.
Primary ExpressionErythrocytes, immune cells, brain (glia), salivary glands
Molecular Weight71 kDa
PathwaysInteraction
UniProt IDQ9UQM4
NCBI Gene ID3782
Ensembl IDENSG00000104970
OMIM604270
GeneCardsKCNN4
Human Protein AtlasKCNN4
Associated DiseasesCancer
InteractionsAPOPTOSIS, NEURON, CYTOKINES, Ras, RNA
KG Connections127 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
PARP1 Inhibition Therapy
Score: 0.58
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

Hippo Signaling in 4R-Tauopathies
mechanism · KG edge: associated_with
erk-mapk-signaling-neurodegeneration
mechanism · KG edge: therapeutic_target
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
KCNK2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

KCNN4 associated_with KCNQ1
KCNN4 associated_with CACNA1C
KCNN4 associated_with KCNK2
KCNN4 associated_with Axon Guidance
KCNN4 therapeutic_target TERT
KCNN4 causes PIEZO2
KCNN4 causes SCN5A
KCNN4 causes TRPV4
KCNN4 causes SCNN1A
KCNN4 causes TRPV1