gene 1,591 words KG: TRPM7 2026-03-27
kind:genesection:genestopic:alzheimerstopic:parkinsonstopic:als
Contents

TRPM7 Gene

🧬 Gene Info
Gene SymbolTRPM7
Full NameTransient Receptor Potential Cation Channel Subfamily M Member 7
AliasesCHAK1 (Channel Kinase 1), LTrpC7, TRP-PLK, MIC
Chromosome15q21.3
Protein TypeChannel
Functionis a unique bifunctional protein that combines an ion channel with a serine/threonine kinase domain.
Amino Acids2035 aa
Exons39
PathwaysBlood-Brain Barrier, pyroptosis
UniProt IDQ9BQZ6
NCBI Gene ID54822
Ensembl IDENSG00000156113
GeneCardsTRPM7
Human Protein AtlasTRPM7
Associated DiseasesCancer, status epilepticus
Known Drugs/CompoundsNS8593
InteractionsNLRP3, Stat3, NEUROINFLAMMATION, IL-18, IL-1, EPILEPSY
KG Connections152 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.66
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Aquaporin-4 Polarization Rescue
Score: 0.51

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Hippo Signaling in 4R-Tauopathies
mechanism · KG edge: associated_with
Autoimmune Hypothesis in Alzheimer's Disease
hypothesis · KG edge: activates
CFTR Gene
gene · KG edge: associated_with
CACNA1C Gene
gene · KG edge: associated_with
CACNA1B Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TRPM7 associated_with SCN1A
TRPM7 associated_with TRPV4
TRPM7 associated_with CACNA1B
TRPM7 associated_with SCNN1A
TRPM7 associated_with CFTR
TRPM7 associated_with PIEZO2
TRPM7 associated_with TRPA1
TRPM7 associated_with KCNMA1
TRPM7 associated_with TRPV1
TRPM7 associated_with KCNN4