| Gene Symbol | SLC9A2 |
| Full Name | Solute Carrier Family 9 Member 2 (Na+/H+ Exchanger 2) |
| Chromosome | 2q31.1 |
| Function | is a member of the SLC9A family of sodium-hydrogen antiporters, which play critical roles in maintaining intracellular pH (pHi), cell volume, and sodium homeostasis. |
| Pathways | Tumor Microenvironment |
| UniProt ID | Q9Y5E8 |
| NCBI Gene ID | 6539 |
| Ensembl ID | ENSG00000165650 |
| OMIM | 231336 |
| GeneCards | SLC9A2 |
| Human Protein Atlas | SLC9A2 |
| N-terminal extracellular domain | Contains glycosylation sites important for protein trafficking and function |
| Transmembrane domain | 11-12 alpha-helical segments that form the ion conduction pathway |
| Hippocampus | Particularly CA1 and CA3 regions, with expression in pyramidal neurons |
| Cerebral cortex | Layer II-V neurons show NHE2 immunoreactivity |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | CANCER, GENES, STAT3 |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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