gene 1,743 words KG: SLC9A2 2026-03-25
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

SLC9A2 — Solute Carrier Family 9 Member 2 (Na+/H+ Exchanger 2)

🧬 Gene Info
Gene SymbolSLC9A2
Full NameSolute Carrier Family 9 Member 2 (Na+/H+ Exchanger 2)
Chromosome2q31.1
Functionis a member of the SLC9A family of sodium-hydrogen antiporters, which play critical roles in maintaining intracellular pH (pHi), cell volume, and sodium homeostasis.
PathwaysTumor Microenvironment
UniProt IDQ9Y5E8
NCBI Gene ID6539
Ensembl IDENSG00000165650
OMIM231336
GeneCardsSLC9A2
Human Protein AtlasSLC9A2
Encoded ProteinNa+/H+ exchanger 2 (NHE2)
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsCANCER, GENES, STAT3
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (1)

Oligodendrocyte White Matter Vulnerability
Score: 0.40

Related Analyses (1)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (6)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (8)

Angiogenesis Pathway
mechanism · KG edge: inhibits
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
VEGFA — Vascular Endothelial Growth Factor A
gene · KG edge: implicated_in
Genes
index · KG edge: inhibits
immunotherapy-update
general · KG edge: inhibits

Knowledge Graph (12 edges)

SLC9A2 implicated_in VEGFA
SLC9A2 inhibits CANCER
SLC9A2 inhibits GENES
SLC9A2 inhibits Colorectal Cancer
SLC9A2 inhibits Cancer
SLC9A2 inhibits Aging
SLC9A2 inhibits Tumor
SLC9A2 inhibits Immunotherapy
SLC9A2 inhibits Epithelial-Mesenchymal Transition
SLC9A2 implicated_in Invasion