| Gene Symbol | SNX2 |
| Function | SNX2 (Sorting Nexin 2) is a key component of the membrane trafficking machinery with multiple essential cellular functions: |
| Molecular Weight | 47 kDa |
| Ensembl ID | ENSG00000136053 |
| GeneCards | SNX2 |
| Human Protein Atlas | SNX2 |
| VPS26/VPS29/VPS35 | The core cargo-selective complex |
| SNX2/SNX1 | The membrane-deforming BAR domain-containing components |
| Cargo Recognition | SNX2 can bind to ubiquitinated cargo destined for autophagic degradation |
| Membrane Bending | The BAR domain of SNX2 induces membrane curvature, facilitating the formation of transport carriers |
| Sorting Decisions | SNX2 helps distinguish between proteins destined for degradation in lysosomes and those destined for recycling to the TGN or plasma membrane |
| Autophagosome Formation | SNX2 contributes to the recruitment of autophagy machinery to nascent autophagosomes |
| Maturation | SNX2 plays a role in autophagosome-endosome/lysosome fusion |
| Amyloidogenesis | Reduced SNX2 expression or function leads to increased APP processing in endosomes, increasing Aβ production. Studies show that SNX2 knockdown increases Aβ secretion in cellular models. |
| Endosomal Dysfunction | AD is characterized by early endosomal vacuolization, and SNX2 dysfunction contributes to this phenotype. This endosomal dysfunction is one of the earliest pathological changes in AD. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |