gene 1,858 words KG: CLN3 2026-03-27
kind:genesection:genesstate:published
Contents

CLN3 Gene - Ceroid Lipofuscinosis, Neuronal 3

🧬 Gene Info
Gene SymbolCLN3
AliasesBatten disease, Battenin
Functionencodes a lysosomal/endosomal transmembrane protein that is critical for neuronal function and survival.
Molecular Weight48 kDa
Amino Acids438 aa
Ensembl IDENSG00000158966
GeneCardsCLN3
Human Protein AtlasCLN3
Associated DiseasesCancer, Cln3 Disease, Ms, Neurodegeneration
KG Connections69 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.50
Microglial Purinergic Reprogramming
Score: 0.48
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.48
Complement C1q Mimetic Decoy Therapy
Score: 0.48

Related Analyses (6)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: biomarker_for
Packard Center for ALS Research
institution · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: therapeutic_target
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
CXCL10 - C-X-C Motif Chemokine Ligand 10
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

CLN3 expressed_in GABARAPL2
CLN3 expressed_in SNX2
CLN3 expressed_in ATG10
CLN3 expressed_in WIPI2
CLN3 therapeutic_target CXCL10
CLN3 therapeutic_target C1QA
CLN3 therapeutic_target TAU
CLN3 therapeutic_target DRD1
CLN3 biomarker_for GPNMB
CLN3 therapeutic_target NLRP3