gene 1,515 words KG: WIPI2 2026-03-24
kind:genesection:genesstate:published
Contents

WIPI2 - WD Repeat Domain, Phosphoinositide Interacting 2

🧬 Gene Info
Gene SymbolWIPI2
Full NameWD Repeat Domain, Phosphoinositide Interacting 2
AliasesPage for WIPI2, WD repeat domain, phosphoinositide-interacting protein 2
Chromosome7q36.3
Protein FamilyPROPPIN family (beta-propeller, PI3P binding)
Functionencodes a 445-amino acid protein with a molecular mass of approximately 46 kDa.
Molecular Weight46 kDa
Amino Acids466 aa
Exons16
PathwaysAutophagy, Cell Cycle, Mitophagy
UniProt IDQ9Y5P9
NCBI Gene ID26100
Ensembl IDENSG00000157911
OMIM609223
GeneCardsWIPI2
Human Protein AtlasWIPI2
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ataxia, Cancer, Carcinoma, Dementia
Known Drugs/Compoundsrapamycin
InteractionsDDB1, PI3K, LC3, UBIQUITIN, ATG16L1, ATG5
KG Connections444 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (12)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.61
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Autophagosome Maturation Checkpoint Control
Score: 0.49

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (16)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
ATG5 — Autophagy Related 5
gene · KG edge: interacts_with
ATG3 Gene
gene · KG edge: expressed_in
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

WIPI2 associated_with BECN1
WIPI2 associated_with HDAC6
WIPI2 associated_with CREBBP
WIPI2 associated_with NBR1
WIPI2 associated_with GAPDH
WIPI2 associated_with HSP70
WIPI2 associated_with NDP52
WIPI2 associated_with VAMP8
WIPI2 associated_with EP300
WIPI2 associated_with MTOR