biomarker 1,403 words KG: CLUSTERIN 2026-03-30
kind:biomarkersection:biomarkersstate:publishedat-category:N
Contents

Clusterin (ApoJ) - AD Biomarker

🔬 Protein Info
Gene SymbolCLU
Full NameClusterin
AliasesPage for CLU Gene
Chromosome8p21.1
Protein FamilyApolipoprotein / extracellular chaperone
FunctionIt binds to non-native, misfolded, or aggregation-prone proteins and maintains them in a soluble state suitable for subsequent processing (Wyatt et al., 2009)
Primary ExpressionSecreted (sCLU), cytoplasmic/nuclear (nCLU/iCLU)
Molecular Weight~75-80 kDa (heterodimer)
Amino Acids522 aa
Exons9
PathwaysApoptosis, Complement, Immune Response, Mitophagy
UniProt IDP10909
NCBI Gene ID1115
Ensembl IDENSG00000120885
OMIM185551
GeneCardsCLU
Human Protein AtlasCLU
Associated DiseasesALS, Aging, Alzheimer, Alzheimer Disease, Alzheimer'S Disease
InteractionsLC3, C1Q, BACE1, PI3K, AKT, BAX
KG Connections292 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Prime Editing Precision Correction of APOE4 to APOE3 in Micr
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Heterogeneous astrocyte activation states differentially imp
Score: 0.52

Related Analyses (26)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived

Related Experiments (8)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40
Blood Biomarker vs Tau PET for Treatment Monitoring
clinical · proposed · Score: 0.40

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: contributes_to
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: activates

Knowledge Graph (12 edges)

CLUSTERIN activates LC3
CLUSTERIN regulates PPARG
CLUSTERIN activates C1Q
CLUSTERIN regulates CR1
CLUSTERIN associated_with CFH
CLUSTERIN activates BACE1
CLUSTERIN regulates LC3
CLUSTERIN regulates PPARGC1A
CLUSTERIN regulates C1S
CLUSTERIN regulates CLU