concept

IRS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

263Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

IRS1 is a concept in neurodegeneration research. Key relationships include: activates, regulates, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 118 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	IRS1
Summary	Insulin Receptor Substrate 1 (IRS-1)
Key Genes/Proteins	KLC1, AKT, PI3K, INSULIN RESISTANCE
Related Diseases	fat distribution, Als, Insulin Resistance
Related Pathways	MAPK Pathway, Mapk, Pi3K/Akt, insulin signaling, insulin signalling
Linked Hypotheses	1 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IRS1["IRS1"]
    IRS1 -->|"regulates"| fat_distribution["fat distribution"]
    IRS1 -->|"regulates"| insulin_signaling["insulin signaling"]
    IRS1 -->|"regulates"| PI3K["PI3K"]
    IRS1 -->|"regulates"| insulin_signalling["insulin signalling"]
    IRS1 -->|"target for"| Senescence["Senescence"]
    IRS1 -->|"target for"| Tumor["Tumor"]
    IRS1 -->|"target for"| Ms["Ms"]
    IRS1 -->|"activates"| Als["Als"]
    IRS1 -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    IRS1 -->|"activates"| Glioma["Glioma"]
    KLC1["KLC1"] -->|"binds"| IRS1
    BRAF["BRAF"] -->|"target for"| IRS1
    CDK1["CDK1"] -->|"target for"| IRS1
    PI3K -->|"activates"| IRS1
    AKT["AKT"] -->|"activates"| IRS1
    VEGFB["VEGFB"] -->|"activates"| IRS1
    TSC1["TSC1"] -->|"regulates"| IRS1
    MTOR["MTOR"] -->|"regulates"| IRS1
    RICTOR["RICTOR"] -->|"regulates"| IRS1

Outgoing (158)

Target	Relation	Type	Str
Oncogene-Induced Senescence	involved_in	process	0.85
fat distribution	regulates	phenotype	0.80
MAPK Pathway	component_of	pathway	0.80
Als	activates	disease	0.75
Insulin Resistance	activates	disease	0.75
Mapk	therapeutic_target	pathway	0.70
AKT	activates	gene	0.70
AKT	inhibits	gene	0.70
Pi3K/Akt	inhibits	pathway	0.70
insulin signaling	regulates	pathway	0.70
PI3K	regulates	protein	0.70
insulin signalling	regulates	pathway	0.70
Senescence	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Glioma	activates	disease	0.65
Senescence	activates	disease	0.65
Tumor	activates	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Tumor	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Type 2 Diabetes	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Diabetes	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Cancer	activates	disease	0.65
Liver Cancer	activates	disease	0.65
Nafld	activates	disease	0.65
Fatty Liver	activates	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Aging	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Depression	activates	disease	0.65
ALS	activates	disease	0.65
Diabetes	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Alzheimer	contributes_to	disease	0.65
Als	contributes_to	disease	0.65
Alzheimer	associated_with	disease	0.65
KIAA1549	therapeutic_target	gene	0.60
Akt	activates	pathway	0.60

Incoming (105)

Source	Relation	Type	Str
KLC1	binds	gene	0.90
resveratrol	reduces_phosphorylation_of	drug	0.90
PI3K	activates	gene	0.70
INSULIN RESISTANCE	activates	gene	0.70
PI3K	inhibits	gene	0.70
ALZHEIMER'S DISEASE	regulates	disease	0.65
BRAF	therapeutic_target	gene	0.60
CDK1	therapeutic_target	gene	0.60
AKT	activates	gene	0.60
VEGFB	activates	gene	0.60
TSC1	regulates	gene	0.60
MTOR	regulates	gene	0.60
PI3K	regulates	gene	0.60
RICTOR	regulates	gene	0.60
AKT	regulates	gene	0.60
PTEN	regulates	gene	0.60
HMOX1	associated_with	gene	0.60
IGF1	associated_with	gene	0.60
KIF20A	associated_with	gene	0.60
G6PD	associated_with	gene	0.60
MCC	therapeutic_target	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
SLC7A11	associated_with	gene	0.60
SPP1	associated_with	gene	0.60
IL6	regulates	gene	0.60
MYC	regulates	gene	0.60
SOD2	regulates	gene	0.60
TNF	regulates	gene	0.60
CANCER	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
BRAF	regulates	gene	0.60
ERK1	activates	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
JNK	activates	gene	0.60
P38	activates	gene	0.60
DIABETES MELLITUS	therapeutic_target	gene	0.60
ROS	activates	gene	0.60
TAU	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
ERK	inhibits	gene	0.60
CANCER	activates	gene	0.60
GENES	inhibits	gene	0.60
KIAA1549::BRAF	regulates	gene	0.60
CDK1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IRS1

Understanding Entity Pages

Summary

Wiki Pages (21)

Insulin Receptor Substrate 1 (IRS-1)

cbs-psp-daily-action-plan

Insulin Signaling in Parkinson's Disease

Type 3 Diabetes Hypothesis of Alzheimer's Disease

Neuroinflammation in Alzheimer's Disease

GSK3B (Glycogen Synthase Kinase 3 Beta)

Insulin Signaling Pathway in Neurodegeneration

Brain Insulin Signaling Pathway

PTPRF Protein

SGK2 Gene

Comprehensive AD Hypothesis Analysis

insulin-resistance-ad

ptp1b-protein

GIGYF2 Protein (GRB10-Interacting GYF Protein 2)

Metabolic Dysfunction and Insulin Signaling Impairment Pathway

IGF1 Gene

IGF1R Gene

IRS-1 (Insulin Receptor Substrate 1)

Insulin-Like Growth Factor 1 Protein

AKT3 Gene