gene 1,311 words KG: STMN2
Contents

STMN2 (Stathmin-2)

🧬 Gene Info
Gene SymbolSTMN2
Chromosome8q21.13
FunctionLike other stathmin family members, it can sequester tubulin dimers, reducing the pool of free tubulin available for microtubule polymerization.
Primary ExpressionMotor Neurons, Cortical Neurons, Sensory Neurons, Developing CNS
Molecular Weight20 kDa
PathwaysAxonal Regeneration
Ensembl IDENSG00000104435
GeneCardsSTMN2
Human Protein AtlasSTMN2
Symbol [@agra2024] STMN2 [@beri2024] [@krus2022] [@pickles2025] Full Name [@allen] Stathmin-2 (Superior Cervical Ganglion 10, SCG10) [@allena] [@allenb] [@allenc] Chromosome [@brainspan] 8q21.13 [@tardbp] [@unca] [@tdp] NCBI Gene [@tdpproteinopathy] 11075 [@als] [@ftd] [@corf] Ensembl [@motorneurons] ENSG00000104435 [@ncbi] [@omim] [@uniprot] OMIM [@ensembl] 600621 [@genecards] [@allend] [@riederer1997] UniProt [@zhu2019] Q93045 [@liu2020] [@brown2011] DiseasesALS, FTD, Alzheimer's Disease, TDP-43 Proteinopathies
Associated DiseasesALS, NEURODEGENERATION, frontotemporal dementia
InteractionsTDP-43, SMN, Rb, UNC13A, ALS, NEURODEGENERATIVE DISEASES
SciDEX HypothesesSTMN2 Restoration as a Prerequisite for Axon Growt
KG Connections124 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Stathmin-2 Splice Switching to Prevent Axonal Degeneration A
Score: 0.66
Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo
Score: 0.47
Arginine Methylation Enhancement Therapy
Score: 0.46
Cryptic Exon Silencing Restoration
Score: 0.46
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Packard Center for ALS Research
institution · KG edge: activates
NEFL — Neurofilament Light Chain
gene · KG edge: activates
CHMP7 mutations cause hereditary spastic paraplegia
gene · KG edge: expressed_in
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: interacts_with
Amyotrophic Lateral Sclerosis
redirect · KG edge: activates

Knowledge Graph (12 edges)

STMN2 activates AXONAL_REGENERATION
STMN2 involved_in Axonal Regeneration
STMN2 expressed_in Motor Neurons
STMN2 downregulates Stress
STMN2 activates TDP-43
STMN2 expressed_in CHMP7
STMN2 interacts_with TDP-43
STMN2 interacts_with SMN
STMN2 interacts_with Rb
STMN2 mediates Axonal Outgrowth