Contents

NEFL — Neurofilament Light Chain

🧬 Gene Info

Gene Symbol	NEFL
Full Name	Neurofilament Light Polypeptide (NF-L, NF68)
Chromosome	8p21.2
Function	These dimers associate in an antiparallel, staggered manner to form tetramers, which then laterally associate into protofilaments and mature 10-nm intermediate filaments.
Primary Expression	Motor Neurons, Cortical Neurons, Peripheral Nerves, All Neurons (ubiquitous)
Molecular Weight	62 kDa
Amino Acids	543 aa
Exons	4
Pathways	Axonal Transport
UniProt ID	P07196
NCBI Gene ID	4747
Ensembl ID	ENSG00000277586
OMIM	162280
GeneCards	NEFL
Human Protein Atlas	NEFL
Associated Diseases	Alzheimers_disease
Interactions	STMN2, PVALB, RANK, CNR1, STATHMIN, NRGN
KG Connections	200 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph