gene 707 words KG: TREM1 2026-03-24
kind:genesection:genesstate:published
Contents

TREM1 — Triggering Receptor Expressed on Myeloid Cells 1

🧬 Gene Info
Gene SymbolTREM1
Full NameTREM1 — Triggering Receptor Expressed on Myeloid Cells 1
Chromosome6p21.1
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Amino Acids234 aa
Exons5
PathwaysNF-κB, MAPK pathway
NCBI Gene ID54206
GeneCardsTREM1
Human Protein AtlasTREM1
Associated Diseasescognitive impairment, neurodegeneration, neuroinflammation
Known Drugs/CompoundsLP17
InteractionsTREM2, LIPOPHAGY, AUTOPHAGY, NLRP3, CD14, TLR4
KG Connections45 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (8)

TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
APOE-TREM2 Interaction Modulation
Score: 0.48

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (14)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (6)

Lipophagy Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
NLRP3 Inflammasome Hypothesis in Parkinson's Disease
hypothesis · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
Microglia in Neurodegeneration
entity · KG edge: activates

Knowledge Graph (12 edges)

TREM1 inhibits lipophagy
TREM1 associated_with neurodegeneration
TREM1 interacts_with TREM2
TREM1 inhibits TREM2
TREM1 biomarker_for Major Adverse Cardiovascular Events
TREM1 therapeutic_target Inflammation
TREM1 activates Diabetes
TREM1 activates Aging
TREM1 therapeutic_target Neuroinflammation
TREM1 activates Inflammasome