gene 2,349 words KG: CD14
Contents

CD14 — CD14 Molecule

🧬 Gene Info
Gene SymbolCD14
Full NameCD14 Molecule
Chromosome5q31.3
Protein TypeReceptor
FunctionIts primary roles include
Primary ExpressionMonocytes, Macrophages, Neutrophils, Microglia
Subcellular LocalizationCell membrane, secreted
Molecular Weight~40 kDa (glycosylated)
Amino Acids382 aa
PathwaysAmyloid, Calcium Signaling, Hedgehog, Nf-Κb, Phagocytosis
UniProt IDP08571
NCBI Gene ID929
Ensembl IDENSG00000144891
OMIM158120
GeneCardsCD14
Human Protein AtlasCD14
Associated DiseasesALS, Alzheimer, Atherosclerosis, Carcinoma, Cardiomyopathy
InteractionsFOXP3, CMKLR1, PPARG, JUN, RGS1, ATF3
KG Connections383 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (10)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: biomarker_for
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
BMAL1 (ARNTL) Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CD14 treats CD4
CD14 treats RORC
CD14 associated_with CD68
CD14 biomarker_for MMP2
CD14 therapeutic_target RORC
CD14 therapeutic_target CD4
CD14 activates FOXP3
CD14 associated_with CD163
CD14 biomarker_for MMP9
CD14 associated_with CD47