gene

CD14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

373Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CD14 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 169 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CD14
Full Name	CD14 Molecule
Chromosome	5q31.3
Protein Type	Receptor
Function	Its primary roles include
Primary Expression	Monocytes, Macrophages, Neutrophils, Microglia
Molecular Weight	40 kDa
Amino Acids	382 aa
Pathways	Amyloid, Calcium Signaling, Hedgehog, Nf-Κb, Phagocytosis
UniProt ID	P08571
NCBI Gene ID	929
Ensembl ID	ENSG00000144891
OMIM	158120
GeneCards	CD14
Human Protein Atlas	CD14
Associated Diseases	Als, Alzheimer, Atherosclerosis, Carcinoma, Cardiomyopathy
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ANXA2
KG Connections	373 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CD14 — AlphaFold P08571 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CD14 — CD14 Molecule

gene · 2349 words

→

Pathway Diagram

graph TD
    CD14["CD14"]
    CD14 -.biomarker for.-> Cancer["Cancer"]
    CD14 -.biomarker for.-> Als["Als"]
    CD14 -.biomarker for.-> Aging["Aging"]
    CD14 -.biomarker for.-> Ms["Ms"]
    CD14 -->|"interacts"| Alzheimer["Alzheimer"]
    CD14 -->|"target for"| Obesity["Obesity"]
    CD14 -->|"target for"| Inflammation["Inflammation"]
    CD14 -->|"regulates"| Arthritis["Arthritis"]
    MMP9["MMP9"] -.biomarker for.-> CD14
    CMKLR1["CMKLR1"] -->|"interacts"| CD14
    RAGE["RAGE"] -->|"interacts"| CD14
    CD4["CD4"] -->|"target for"| CD14
    ICAM1["ICAM1"] -->|"activates"| CD14
    TREM2["TREM2"] -->|"activates"| CD14
    TLR2["TLR2"] -->|"activates"| CD14
    NFKBIA["NFKBIA"] -->|"activates"| CD14
    MRC1["MRC1"] -->|"activates"| CD14
    IL1B["IL1B"] -->|"activates"| CD14

Outgoing (274)

Target	Relation	Type	Str
monocyte/macrophage differentiation	involved_in	process	0.90
macrophages	expressed_in	cell_type	0.80
Als	associated_with	disease	0.75
Als	causes	disease	0.75
Inflammation	associated_with	disease	0.75
Nf-Κb	activates	pathway	0.70
NF-ΚB	activates	gene	0.70
Obesity	therapeutic_target	disease	0.65
Myocardial Infarction	associated_with	disease	0.65
Psoriasis	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Aging	activates	disease	0.65
Coronary Artery Disease	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Carcinoma	causes	disease	0.65
Inflammation	degrades	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Infection	interacts_with	disease	0.65
Als	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Obesity	inhibits	disease	0.65
Ms	regulates	disease	0.65
Obesity	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Senescence	regulates	disease	0.65
Infection	regulates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Inflammation	causes	disease	0.65
Hepatocellular Carcinoma	causes	disease	0.65
Als	interacts_with	disease	0.65
ALS	biomarker_for	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	biomarker_for	disease	0.65
Als	inhibits	disease	0.65
Ms	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Ischemia	activates	disease	0.65
Autoimmune	activates	disease	0.65
ALS	activates	disease	0.65
Obesity	activates	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Arthritis	regulates	disease	0.65
Ms	expressed_in	disease	0.65

Incoming (99)

Source	Relation	Type	Str
TREM2	activates	gene	0.70
TLR2	activates	gene	0.60
NFKBIA	activates	gene	0.60
MRC1	activates	gene	0.60
IL1B	activates	gene	0.60
ITGAM	activates	gene	0.60
TNF	activates	gene	0.60
CXCL2	activates	gene	0.60
ANXA2	activates	gene	0.60
CD44	activates	gene	0.60
HMOX1	activates	gene	0.60
SPP1	activates	gene	0.60
TIMP1	activates	gene	0.60
LGALS3	activates	gene	0.60
CD8	associated_with	gene	0.60
CXCL10	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
NRP1	associated_with	gene	0.60
INFLAMMATION	degrades	gene	0.60
INFLAMMATION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
ROS	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
MRPS31	associated_with	gene	0.60
ICAM1	activates	gene	0.60
INOS	activates	gene	0.60
FOXP3	activates	gene	0.60
RORC	associated_with	gene	0.60
CD4	associated_with	gene	0.60
TNF	therapeutic_target	gene	0.60
PI3K	activates	gene	0.60
TLR4	regulates	gene	0.60
MYD88	regulates	gene	0.60
TIRAP	activates	gene	0.60
DOT1L	regulates	gene	0.60
PIEZO1	regulates	gene	0.60
TIMMDC1	therapeutic_target	gene	0.60
BCS1L	associated_with	gene	0.60
APOC1	activates	gene	0.60
C1QA	activates	gene	0.60
C1QC	activates	gene	0.60
AND	inhibits	gene	0.60
CD163	degrades	gene	0.60
MMP2	biomarker_for	gene	0.60
RORC	therapeutic_target	gene	0.60
GPR109A	activates	gene	0.60
P53	activates	gene	0.60
NF-ΚB	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

closed · Rounds: 4 · Score: 0.82 · 2026-04-22

Related Research

Hypotheses and analyses mentioning CD14 in their description or question text

No additional research found