gene

CD14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

383Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CD14 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 169 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD14
Full Name	CD14 Molecule
Chromosome	5q31.3
Protein Type	Receptor
Function	Its primary roles include
Primary Expression	Monocytes, Macrophages, Neutrophils, Microglia
Subcellular Localization	Cell membrane, secreted
Molecular Weight	~40 kDa (glycosylated)
Amino Acids	382 aa
Pathways	Amyloid, Calcium Signaling, Hedgehog, Nf-Κb, Phagocytosis
UniProt ID	P08571
NCBI Gene ID	929
Ensembl ID	ENSG00000144891
OMIM	158120
GeneCards	CD14
Human Protein Atlas	CD14
Associated Diseases	ALS, Alzheimer, Atherosclerosis, Carcinoma, Cardiomyopathy
Interactions	FOXP3, CMKLR1, PPARG, JUN, RGS1, ATF3
KG Connections	383 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CD14 — AlphaFold P08571 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD14["CD14"]
    CD14 -.biomarker for.-> Cancer["Cancer"]
    CD14 -.biomarker for.-> Als["Als"]
    CD14 -.biomarker for.-> Aging["Aging"]
    CD14 -.biomarker for.-> Ms["Ms"]
    CD14 -->|"interacts"| Alzheimer["Alzheimer"]
    CD14 -->|"target for"| Obesity["Obesity"]
    CD14 -->|"target for"| Inflammation["Inflammation"]
    CD14 -->|"regulates"| Arthritis["Arthritis"]
    MMP9["MMP9"] -.biomarker for.-> CD14
    CMKLR1["CMKLR1"] -->|"interacts"| CD14
    RAGE["RAGE"] -->|"interacts"| CD14
    CD4["CD4"] -->|"target for"| CD14
    ICAM1["ICAM1"] -->|"activates"| CD14
    TREM2["TREM2"] -->|"activates"| CD14
    TLR2["TLR2"] -->|"activates"| CD14
    NFKBIA["NFKBIA"] -->|"activates"| CD14
    MRC1["MRC1"] -->|"activates"| CD14
    IL1B["IL1B"] -->|"activates"| CD14

Outgoing (284)

Target	Relation	Type	Str
monocyte/macrophage differentiation	involved_in	process	0.90
macrophages	expressed_in	cell_type	0.80
Inflammation	associated_with	disease	0.75
Als	associated_with	disease	0.75
Als	causes	disease	0.75
Nf-Κb	activates	pathway	0.70
NF-ΚB	activates	gene	0.70
Arthritis	regulates	disease	0.65
Cancer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Alzheimer	interacts_with	disease	0.65
Obesity	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Obesity	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Inflammation	activates	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Ischemia	activates	disease	0.65
Senescence	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	interacts_with	disease	0.65
ALS	biomarker_for	disease	0.65
Inflammation	degrades	disease	0.65
ALS	associated_with	disease	0.65
Obesity	activates	disease	0.65
Inflammation	causes	disease	0.65
Psoriasis	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Als	implicated_in	disease	0.65
Myocardial Infarction	associated_with	disease	0.65
Coronary Artery Disease	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Carcinoma	causes	disease	0.65
Hepatocellular Carcinoma	causes	disease	0.65
Carcinoma	associated_with	disease	0.65
Cirrhosis	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Infection	interacts_with	disease	0.65
Aging	activates	disease	0.65
Infection	regulates	disease	0.65
Als	regulates	disease	0.65
Covid	interacts_with	disease	0.65

Incoming (99)

Source	Relation	Type	Str
TREM2	activates	gene	0.70
CD163	associated_with	gene	0.60
MMP9	biomarker_for	gene	0.60
CD47	associated_with	gene	0.60
TLR2	associated_with	gene	0.60
CD36	associated_with	gene	0.60
CMKLR1	interacts_with	gene	0.60
RAGE	interacts_with	gene	0.60
TLR4	associated_with	gene	0.60
CD68	associated_with	gene	0.60
CD4	therapeutic_target	gene	0.60
ICAM1	activates	gene	0.60
TLR2	activates	gene	0.60
NFKBIA	activates	gene	0.60
MRC1	activates	gene	0.60
IL1B	activates	gene	0.60
ITGAM	activates	gene	0.60
TNF	activates	gene	0.60
CXCL2	activates	gene	0.60
ANXA2	activates	gene	0.60
CD44	activates	gene	0.60
HMOX1	activates	gene	0.60
SPP1	activates	gene	0.60
TIMP1	activates	gene	0.60
LGALS3	activates	gene	0.60
TLR4	activates	gene	0.60
FOXP3	activates	gene	0.60
RORC	associated_with	gene	0.60
CD4	associated_with	gene	0.60
CD163	degrades	gene	0.60
MMP2	biomarker_for	gene	0.60
TNF	therapeutic_target	gene	0.60
PI3K	activates	gene	0.60
CD8	associated_with	gene	0.60
CXCL10	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
NRP1	associated_with	gene	0.60
TLR4	regulates	gene	0.60
MYD88	regulates	gene	0.60
TIRAP	activates	gene	0.60
NLRP3	regulates	gene	0.60
DOT1L	regulates	gene	0.60
PIEZO1	regulates	gene	0.60
TIMMDC1	therapeutic_target	gene	0.60
RORC	therapeutic_target	gene	0.60
TIMMDC1	associated_with	gene	0.60
LYRM7	associated_with	gene	0.60
GPR109A	activates	gene	0.60
FBXO7	associated_with	gene	0.60
BCS1L	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CD14

Understanding Entity Pages

Summary

Wiki Pages (21)

CD14 — CD14 Molecule

Microglial Cells — Cell Type Hierarchy

Alpha-Synuclein Prion-Like Spreading Mechanisms in Parkinson's Disease

Amyloid-Beta Aggregation and Plaque Formation

Gut-Microbiome-Neurodegeneration Axis

Neuroinflammation in Amyotrophic Lateral Sclerosis

FBXO7 — F-Box Protein 7

Microglia Activation Mechanism

Neuroinflammation in Neurodegeneration

Cyclophosphamide

neuroinflammation-ad-pd-als

TREML1 (TREM Like Transcript 1)

Peripheral Immune System in Parkinson's Disease

Amyloid-Tau Synergistic Interaction Hypothesis

Neuroimmune Biomarkers in Progressive Supranuclear Palsy

Cell Type Atlas

Innate Immune Pattern Recognition in 4R-Tauopathies

NLRP3 Inflammasome Inhibitors for Parkinson's Disease

Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts