gene 1,635 words KG: SOX9 2026-03-28
kind:genesection:genesstate:published
Contents

SOX9 Gene

🧬 Gene Info
Gene SymbolSOX9
Full NameSRY-Box Transcription Factor 9
AliasesSOX-9, CMD1, SRA1
Chromosome17q24.3
Protein FamilySOX family (Sry-related HMG box)
Protein TypeTranscription Factor
Functionencodes a high-mobility-group (HMG) box transcription factor essential for chondrogenesis, neural crest development, sex determination, and glial cell differentiation.
Subcellular LocalizationNucleus
Molecular Weight~56 kDa (509 amino acids)
Amino Acids509 aa
Gene TypeProtein coding
PathwaysApoptosis, Autophagy, Cell Cycle, Epigenetic, Hedgehog
UniProt IDP48436
NCBI Gene ID6662
Ensembl IDENSG00000125398
OMIM608161
GeneCardsSOX9
Human Protein AtlasSOX9
Associated DiseasesCancer, Cardiovascular, Ischemia, Ms, Neurodegeneration, Parkinson
Known Drugs/Compoundsrapamycin
InteractionsSLC7A11, MMP1, FER, MMP3, AKT, LC3
KG Connections367 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.38
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: inhibits
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
ATF3 Gene
gene · KG edge: activates
ar
gene · KG edge: activates

Knowledge Graph (12 edges)

SOX9 associated_with WDR45
SOX9 associated_with BECN1
SOX9 associated_with HDAC6
SOX9 associated_with ESR1
SOX9 associated_with PSEN1
SOX9 associated_with MAP1LC3B
SOX9 associated_with UVRAG
SOX9 associated_with APP
SOX9 associated_with MTOR
SOX9 associated_with PIK3C3