| Gene Symbol | HDAC8 |
| Chromosome | Xq13.1 |
| Protein Type | Gene |
| Function | encodes a zinc-dependent class I histone deacetylase enzyme that plays a critical role in epigenetic regulation of gene expression. |
| Primary Expression | various tissues, with significant expression in the brain where it regulates chromatin structure and gene transcription essential for neuronal develop |
| Molecular Weight | 42 kDa |
| Amino Acids | 377 aa |
| Exons | 14 |
| Pathways | NF-κB, NF-κB pathway |
| GeneCards | HDAC8 |
| Human Protein Atlas | HDAC8 |
| [Tau](/proteins/tau) pathology | HDAC8 activity affects tau phosphorylation and aggregation. Studies demonstrate that HDAC8 inhibition reduces tau hyperphosphorylation and neurofibrillary tangle formation [7]. |
| Epigenetic dysregulation | Global histone hypoacetylation is observed in AD brain tissue, and HDAC8 contributes to this epigenetic abnormality [8]. |
| Synaptic plasticity | HDAC8 regulates genes critical for synaptic function and memory formation. HDAC8 activity is elevated in AD, leading to transcriptional repression of neuroprotective genes [9]. |
| Dopaminergic neuron survival | HDAC8 activity affects the expression of genes critical for dopaminergic neuron function and survival. HDAC8 inhibitors have shown neuroprotective effects in PD models [10]. |
| Associated Diseases | Als, Alzheimer |
| Interactions | AND, APOPTOSIS, App, BAX, Bcl-2, BCL-2 |
| KG Connections | 142 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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