protein

IΚBΑ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IΚBΑ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

17Outgoing

24Incoming

0Experiments

0Debates

Summary

NFKBIA-encoded inhibitor of NF-κB signaling — IκBα structure, function, phosphorylation, role in neuroinflammation and neurodegeneration

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🔬 Protein Info

Gene Symbol	IΚBΑ
Function	inhibitor of NF-κB signaling — IκBα structure
Pathways	NF-κB, NFKB, nfkb, NF-κB signaling
Interactions	C-FOS, C-JUN, HNRNPU, HO-1, IL-1Β, IL-6
KG Connections	31 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    I_B_["IKappaBAlpha"]
    IL_1_["IL-1Beta"]
    I_B_ -->|"inhibits"| IL_1_
    IL_6["IL-6"]
    I_B_ -->|"inhibits"| IL_6
    IL_8["IL-8"]
    I_B_ -->|"inhibits"| IL_8
    NF__B["NF-kappaB"]
    I_B_ -->|"activates"| NF__B
    inflammation["inflammation"]
    I_B_ -->|"activates"| inflammation
    MAPK["MAPK"]
    I_B_ -->|"activates"| MAPK
    TNF__["TNF-alpha"]
    I_B_ -->|"activates"| TNF__
    CYTOKINE["CYTOKINE"]
    I_B_ -->|"activates"| CYTOKINE
    MAPK_SIGNALING["MAPK SIGNALING"]
    I_B_ -->|"activates"| MAPK_SIGNALING
    BERBERINE["BERBERINE"]
    I_B_ -->|"activates"| BERBERINE
    AMPK["AMPK"]
    I_B_ -->|"expressed in"| AMPK
    NF__B["NF-kappaB"]
    I_B_ -->|"expressed in"| NF__B
    TNF__["TNF-alpha"]
    I_B_ -->|"expressed in"| TNF__
    HO_1["HO-1"]
    I_B_ -->|"inhibits"| HO_1
    NF__B["NF-kappaB"]
    I_B_ -->|"inhibits"| NF__B
    NF__B["NF-KappaB"]
    NF__B -->|"activates"| I_B_
    microglia["microglia"]
    microglia -->|"activates"| I_B_
    TGM2["TGM2"]
    TGM2 -->|"activates"| I_B_
    HNRNPU["HNRNPU"]
    HNRNPU -->|"activates"| I_B_
    STAT1["STAT1"]
    STAT1 -->|"activates"| I_B_
    IL_6["IL-6"]
    IL_6 -->|"activates"| I_B_
    IL_1_["IL-1Beta"]
    IL_1_ -->|"activates"| I_B_
    SIRT1["SIRT1"]
    SIRT1 -->|"expressed in"| I_B_
    IL_6["IL-6"]
    IL_6 -->|"expressed in"| I_B_
    IL_1_["IL-1Beta"]
    IL_1_ -->|"expressed in"| I_B_
    NRF2["NRF2"]
    NRF2 -->|"inhibits"| I_B_
    C_JUN["C-JUN"]
    C_JUN -->|"inhibits"| I_B_
    C_FOS["C-FOS"]
    C_FOS -->|"inhibits"| I_B_
    IL_6["IL-6"]
    IL_6 -->|"inhibits"| I_B_
    IL_1_["IL-1Beta"]
    IL_1_ -->|"inhibits"| I_B_

Outgoing (17)

Target	Relation	Type	Str
NF-κB	inhibits	pathway	0.90
NF-κB	drives_nuclear_translocation_of	pathway	0.80
IL-1Β	inhibits	protein	0.50
IL-6	inhibits	protein	0.50
IL-8	inhibits	protein	0.50
HO-1	inhibits	protein	0.50
NF-κB	inhibits	concept	0.50
NF-κB	activates	concept	0.50
inflammation	activates	pathway	0.50
MAPK	activates	gene	0.50
TNF-α	activates	concept	0.50
CYTOKINE	activates	concept	0.50
MAPK SIGNALING	activates	concept	0.50
BERBERINE	activates	concept	0.50
AMPK	expressed_in	protein	0.50
NF-κB	expressed_in	concept	0.50
TNF-α	expressed_in	concept	0.50

Incoming (24)

Source	Relation	Type	Str
HK2	phosphorylates	protein	0.95
berberine	inhibits	drug	0.90
Tgm2	covalent_cross-linking	gene	0.90
Berberine	inhibits	compound	0.90
TGM2	associated_with	gene	0.90
hnRNPU	interacts_with	protein	0.88
TGMG2	covalently_cross-links	gene	0.80
NF-κB	regulates	pathway	0.80
HNRNPU	activates	gene	0.50
NRF2	inhibits	gene	0.50
C-JUN	inhibits	protein	0.50
C-FOS	inhibits	protein	0.50
microglia	activates	cell_type	0.50
TGM2	activates	gene	0.50
IL-6	activates	protein	0.50
IL-1Β	activates	protein	0.50
SIRT1	expressed_in	gene	0.50
IL-6	expressed_in	protein	0.50
IL-1Β	expressed_in	protein	0.50
IL-6	inhibits	protein	0.50
IL-1Β	inhibits	protein	0.50
IL-8	inhibits	protein	0.50
STAT1	activates	gene	0.50
NF-ΚB	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IΚBΑ in their description or question text

No additional research found