TGM2

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Transglutaminase 2 (TGM2) is a calcium-dependent enzyme that catalyzes protein cross-linking, implicated in neurodegenerative diseases including Alzheimer's, Parkinson's, and Huntington's disease through promotion of protein aggregation.

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flowchart TD
    TGM2["TGM2<br/>(Transglutaminase 2)"]
    
    %% Protective mechanisms
    TGM2 --|"inhibits"|--> Inflammation["Inflammation"]
    TGM2 --|"inhibits"|--> Neuroinflammation["Neuroinflammation"]
    TGM2 --|"inhibits"|--> Senescence["Cellular<br/>Senescence"]
    TGM2 --|"inhibits"|--> Aging["Aging<br/>Process"]
    
    %% Neurodegenerative diseases
    TGM2 --|"regulates"|--> Neurodegeneration["Neurodegeneration"]
    TGM2 --|"inhibits"|--> Alzheimer["Alzheimer's<br/>Disease"]
    TGM2 --|"associated_with"|--> Dementia["Dementia"]
    TGM2 --|"associated_with"|--> ALS["ALS"]
    TGM2 --|"regulates"|--> MS["Multiple<br/>Sclerosis"]
    
    %% Psychiatric conditions
    TGM2 --|"associated_with"|--> Schizophrenia["Schizophrenia"]
    TGM2 --|"associated_with"|--> Depression["Depression"]
    TGM2 --|"associated_with"|--> Anxiety["Anxiety"]
    TGM2 --|"associated_with"|--> Autism["Autism"]
    
    %% Cancer pathways
    TGM2 --|"regulates"|--> Cancer["Cancer"]
    TGM2 --|"biomarker_for"|--> Glioblastoma["Glioblastoma<br/>Multiforme"]
    TGM2 --|"promotes"|--> Radioresistance["Radioresistance"]
    
    %% Therapeutic implications
    Radioresistance --|"reduces_efficacy"|--> Radiotherapy["Radiotherapy<br/>Treatment"]
    
    style TGM2 fill:#006494
    style Inflammation fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style Senescence fill:#ef5350
    style Aging fill:#ef5350
    style Neurodegeneration fill:#ef5350
    style Alzheimer fill:#ef5350
    style Dementia fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Schizophrenia fill:#5d4400
    style Depression fill:#5d4400
    style Anxiety fill:#5d4400
    style Autism fill:#5d4400
    style Cancer fill:#ef5350
    style Glioblastoma fill:#ef5350
    style Radioresistance fill:#ef5350
    style Radiotherapy fill:#1b5e20