SciDEX — BERBERINE

graph TD
    BERBERINE["BERBERINE"]
    BERBERINE -->|"inhibits"| Inflammation["Inflammation"]
    BERBERINE -->|"attenuates"| inflammatory_response["inflammatory response"]
    BERBERINE -->|"inhibits"| IL_1_["IL-1beta"]
    BERBERINE -->|"inhibits"| IL_6["IL-6"]
    BERBERINE -->|"inhibits"| TNF__["TNF-alpha"]
    BERBERINE -->|"inhibits"| NF__B_Signaling_Pathway["NF-kappaB Signaling Pathway"]
    BERBERINE -->|"targets"| IRGM1["IRGM1"]
    BERBERINE -->|"inhibits"| MAPK_Signaling_Pathway["MAPK Signaling Pathway"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"implicated in"| BERBERINE
    BCL2["BCL2"] -->|"target for"| BERBERINE
    APP["APP"] -->|"target for"| BERBERINE
    BAX["BAX"] -->|"target for"| BERBERINE

Outgoing (111)

Target	Relation	Type	Str
INFLAMMATION	treats	phenotype	0.65
NEUROINFLAMMATION	treats	phenotype	0.65
NEUROINFLAMMATION	protects_against	phenotype	0.65
NLRP3 INFLAMMASOME	treats	pathway	0.65
NLRP3 INFLAMMASOME	inhibits	pathway	0.65
AMYLOID-BETA	treats	protein	0.65
AMPK	activates	gene	0.65
TYROBP	activates	gene	0.65
TYROBP	regulates	gene	0.65
ALZHEIMER'S DISEASE	inhibits	disease	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
CYTOKINES	treats	phenotype	0.65
PI3K	interacts_with	gene	0.65
ISCHEMIA	associated_with	disease	0.50
DOPAMINE	associated_with	phenotype	0.45
STAT1	associated_with	gene	0.45
MAPK	associated_with	gene	0.45
TNF	associated_with	gene	0.45
SEPSIS	associated_with	disease	0.45
APP	associated_with	gene	0.45
BAX	associated_with	gene	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
QUERCETIN	associated_with	drug	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
NLRP3	associated_with	gene	0.45
CYTOKINES	associated_with	phenotype	0.45
CORTEX	associated_with	brain_region	0.45
CURCUMIN	associated_with	drug	0.45
AMYLOID	associated_with	protein	0.45
AMPK	associated_with	gene	0.45
TYROBP	associated_with	gene	0.45
BACE1	associated_with	gene	0.45
AUTOPHAGY	associated_with	phenotype	0.45
SIRT1	associated_with	gene	0.45
PI3K	associated_with	gene	0.45
BDNF	associated_with	gene	0.45
AKT	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
INFLAMMATION	biomarker_for	process	0.35
INFLAMMATION	associated_with	process	0.35
MAPK SIGNALING	activates	process	0.35
INFLAMMATION	activates	process	0.35
NF-KB	activates	gene	0.35
IL-6	activates	gene	0.35
TNF	activates	gene	0.35
NEUROINFLAMMATION	inhibits	process	0.35
SEPSIS	inhibits	disease	0.35
QUERCETIN	interacts_with	drug	0.35
CASP3	therapeutic_target	gene	0.35
SOD2	therapeutic_target	gene	0.35

Incoming (54)

Source	Relation	Type	Str
HIPPOCAMPUS	treats	brain_region	0.65
OXIDATIVE STRESS	implicated_in	phenotype	0.55
inflammation	inhibits	pathway	0.50
inflammation	associated_with	pathway	0.50
disease	associated_with	disease	0.50
STAT1	activates	gene	0.50
IL-6	activates	protein	0.50
IL-1Β	activates	protein	0.50
IΚBΑ	activates	protein	0.50
inflammation	activates	pathway	0.50
MAPK	activates	gene	0.50
NF-κB	activates	concept	0.50
TNF-α	activates	concept	0.50
CYTOKINE	activates	concept	0.50
MAPK SIGNALING	activates	concept	0.50
Autoimmune	activates	disease	0.50
Ulcerative Colitis	inhibits	disease	0.50
Ulcerative Colitis	associated_with	disease	0.50
Endocytosis	regulates	pathway	0.50
DOPAMINE	regulates	concept	0.50
AKT1	interacts_with	gene	0.50
Neuroinflammation	inhibits	process	0.50
Sepsis	inhibits	disease	0.50
QUERCETIN	interacts_with	concept	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
IL1B	associated_with	gene	0.50
MAPT	associated_with	gene	0.50
HMOX1	associated_with	gene	0.50
BCL2	associated_with	gene	0.50
SOD2	associated_with	gene	0.50
CASP3	associated_with	gene	0.50
ACHE	associated_with	concept	0.50
oxidative stress	regulates	phenotype	0.50
NEUROINFLAMMATION	associated_with	phenotype	0.45
QUERCETIN	associated_with	drug	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
APP	associated_with	gene	0.45
BAX	associated_with	gene	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
PREFRONTAL CORTEX	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
SYNAPTIC PLASTICITY	associated_with	phenotype	0.45
NEUROGENESIS	associated_with	phenotype	0.45
RESVERATROL	associated_with	drug	0.45
AMYLOID-BETA	associated_with	protein	0.45
METFORMIN	associated_with	drug	0.45
NICOTINAMIDE	associated_with	drug	0.45
ALZHEIMER'S DISEASE	implicated_in	disease	0.35

Name	BERBERINE
Key Genes/Proteins	AMYLOID-BETA, AMPK, TYROBP, PI3K
Related Diseases	INFLAMMATION, NEUROINFLAMMATION, ALZHEIMER'S DISEASE, CYTOKINES, OXIDATIVE STRESS
Related Pathways	NLRP3 INFLAMMASOME

BERBERINE

Understanding Entity Pages

Wiki Pages (20)

neuroinflammation

TFAM Gene

AMPK Signaling Pathway

neuroinflammation-ad-pd-als

PGC-1α (PPARGC1A)

Pathway Diagram

Outgoing (111)

Incoming (54)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)

BERBERINE

Understanding Entity Pages

Wiki Pages (20)

neuroinflammation

TFAM Gene

AMPK Signaling Pathway

neuroinflammation-ad-pd-als

PGC-1α (PPARGC1A)

fip200

Glial Fibrillary Acidic Protein (GFAP)

Adiponectin Receptor Modulator Therapies

Autophagy Molecular Regulation in Neurodegeneration

AMPK Signaling in Neurodegeneration

Section 194: Advanced Mitochondrial Dynamics and Biogenesis Therapy in CBS/PSP

Section 125 — Advanced Ketogenic and Metabolic Therapy for CBS/PSP

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

AMPK Activators for Neurodegeneration

Section 201: Advanced Mitochondrial Biogenesis and PGC-1α Targeting in CBS/PSP

PRKAB1 — Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1

Section 201: Advanced Mitochondrial Biogenesis and PGC-1α Targeting in CBS/PSP

AD AMPK Activator and Energy Metabolism Companies

aim2-inflammasome-modulator-therapy

GFAP (Glial Fibrillary Acidic Protein)

Pathway Diagram

Outgoing (111)

Incoming (54)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)